STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Lbys_2162Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (820 aa)    
Predicted Functional Partners:
Lbys_2281
COGs: COG0208 Ribonucleotide reductase beta subunit; InterPro IPR000358; KEGG: sli:Slin_5045 ribonucleoside-diphosphate reductase; PFAM: ribonucleotide reductase; PRIAM: Ribonucleoside-diphosphate reductase; SPTR: Ribonucleoside-diphosphate reductase; PFAM: Ribonucleotide reductase, small chain.
 
 0.997
Lbys_2075
COGs: COG0208 Ribonucleotide reductase beta subunit; InterPro IPR000358; KEGG: fjo:Fjoh_4066 ribonucleotide reductase; PFAM: ribonucleotide reductase; SPTR: Ribonucleotide reductase; PFAM: Ribonucleotide reductase, small chain.
  
 0.991
cmk
COGs: COG0283 Cytidylate kinase; InterPro IPR011994:IPR003136; KEGG: dfe:Dfer_5748 cytidylate kinase; PFAM: cytidylate kinase region; SPTR: Cytidylate kinase; TIGRFAM: cytidylate kinase; PFAM: Cytidylate kinase; TIGRFAM: cytidylate kinase.
  
 
 0.915
adk
Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.
     
 0.911
Lbys_2896
COGs: COG0105 Nucleoside diphosphate kinase; InterPro IPR001564; KEGG: sli:Slin_6029 nucleoside-diphosphate kinase; PFAM: nucleoside diphosphate kinase; PRIAM: Nucleoside-diphosphate kinase; SMART: nucleoside diphosphate kinase; SPTR: Nucleoside-diphosphate kinase; PFAM: Nucleoside diphosphate kinase; Belongs to the NDK family.
     
 0.910
Lbys_2076
Ribonucleoside-diphosphate reductase, alpha chain; InterPro IPR000788:IPR013350; KEGG: fjo:Fjoh_4065 ribonucleotide-diphosphate reductase subunit alpha; PFAM: ribonucleotide reductase large subunit; SPTR: Ribonucleoside-diphosphate reductase, alpha chain; TIGRFAM: ribonucleoside-diphosphate reductase, alpha chain; PFAM: Ribonucleotide reductase, barrel domain; TIGRFAM: ribonucleoside-diphosphate reductase, alpha chain.
  
  
 
0.906
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
     
 0.902
Lbys_2933
(p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
   
 
  0.901
Lbys_2209
Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.
     
 
0.900
Lbys_2554
Protein of unknown function DUF179; COGs: COG1678 Putative transcriptional regulator protein; InterPro IPR003774; KEGG: dfe:Dfer_4074 protein of unknown function DUF179; PFAM: protein of unknown function DUF179; SPTR: UPF0301 protein M23134_01239; PFAM: Uncharacterized ACR, COG1678; Belongs to the UPF0301 (AlgH) family.
   
 0.894
Your Current Organism:
Leadbetterella byssophila
NCBI taxonomy Id: 649349
Other names: L. byssophila DSM 17132, Leadbetterella byssophila 4M15, Leadbetterella byssophila DSM 17132, Leadbetterella byssophila str. DSM 17132, Leadbetterella byssophila strain DSM 17132
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