close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
trpFCOGs: COG0135 Phosphoribosylanthranilate isomerase; InterPro IPR001240; KEGG: sli:Slin_5476 phosphoribosylanthranilate isomerase; PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); PRIAM: Phosphoribosylanthranilate isomerase; SPTR: N-(5'-phosphoribosyl)anthranilate isomerase; PFAM: N-(5'phosphoribosyl)anthranilate (PRA) isomerase; Belongs to the TrpF family. (204 aa)    
Predicted Functional Partners:
trpB
Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
  
 0.999
Lbys_2386
COGs: COG0134 Indole-3-glycerol phosphate synthase; InterPro IPR001468:IPR013798; KEGG: phe:Phep_4168 indole-3-glycerol-phosphate synthase; PFAM: Indole-3-glycerol phosphate synthase; PRIAM: Indole-3-glycerol-phosphate synthase; SPTR: Indole-3-glycerol-phosphate synthase; PFAM: Indole-3-glycerol phosphate synthase; Belongs to the TrpC family.
 
 0.999
trpD
Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA).
 
 
 0.996
trpA
Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
  
 0.987
Lbys_2173
COGs: COG0147 Anthranilate/para-aminobenzoate synthase component I; InterPro IPR019999:IPR006805:IPR015890; KEGG: dfe:Dfer_3790 anthranilate synthase; PFAM: Chorismate binding-like; Anthranilate synthase component I domain protein; PRIAM: Anthranilate synthase; SPTR: Anthranilate synthase; PFAM: Anthranilate synthase component I, N terminal region; chorismate binding enzyme.
 
  
 0.953
Lbys_2174
COGs: COG0512 Anthranilate/para-aminobenzoate synthase component II; InterProIPR006220:IPR011702:IPR001317:IPR006221:IPR 000991:IPR017926; KEGG: sli:Slin_5473 glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; SPTR: Glutamine amidotransferase of anthranilate synthase; TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: Glutamine amidotransferase class-I; TIGRFAM: glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase.
 
  
 0.951
Lbys_3208
Chorismate binding protein; COGs: COG0147 Anthranilate/para-aminobenzoate synthase component I; InterPro IPR015890; KEGG: bth:BT_0767 para-aminobenzoate synthase component I; PFAM: Chorismate binding-like; SPTR: Putative para-aminobenzoate synthase component I; PFAM: chorismate binding enzyme.
 
  
 0.901
Lbys_2383
KEGG: sli:Slin_3395 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.773
hisI
phosphoribosyl-ATP diphosphatase; COGs: COG0139 Phosphoribosyl-AMP cyclohydrolase; InterPro IPR008179:IPR002496:IPR021130; KEGG: sli:Slin_5481 phosphoribosyl-ATP diphosphatase; PFAM: Phosphoribosyl-ATP pyrophosphohydrolase-like; phosphoribosyl-AMP cyclohydrolase; SPTR: Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase; TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: Phosphoribosyl-ATP pyrophosphohydrolase; Phosphoribosyl-AMP cyclohydrolase; TIGRFAM: phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family.
  
  
 0.606
Lbys_2387
RNA polymerase, sigma-24 subunit, ECF subfamily; COGs: COG1595 DNA-directed RNA polymerase specialized sigma subunit sigma24 homolog; InterPro IPR014284:IPR007627:IPR013249; KEGG: sli:Slin_5681 RNA polymerase, sigma-24 subunit, ECF subfamily; PFAM: Sigma-70 region 4 type 2; sigma-70 region 2 domain protein; SPTR: RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: Sigma-70, region 4; Sigma-70 region 2; TIGRFAM: RNA polymerase sigma factor, sigma-70 family.
       0.528
Your Current Organism:
Leadbetterella byssophila
NCBI taxonomy Id: 649349
Other names: L. byssophila DSM 17132, Leadbetterella byssophila 4M15, Leadbetterella byssophila DSM 17132, Leadbetterella byssophila str. DSM 17132, Leadbetterella byssophila strain DSM 17132
Server load: medium (58%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.