STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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[Homology]
Score
Lbys_3531AAA ATPase central domain protein; COGs: COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase; InterPro IPR008824:IPR003959:IPR003593; KEGG: dfe:Dfer_5733 AAA ATPase central domain protein; PFAM: AAA ATPase central domain protein; Holliday junction DNA helicase RuvB domain; SMART: AAA ATPase; SPTR: AAA ATPase central domain protein; PFAM: MgsA AAA+ ATPase C terminal; ATPase family associated with various cellular activities (AAA). (422 aa)    
Predicted Functional Partners:
Lbys_2252
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
 
 
 
 0.841
Lbys_1113
ATP-dependent DNA helicase, RecQ family; COGs: COG0514 Superfamily II DNA helicase; InterProIPR011545:IPR001650:IPR018329:IPR014021:IPR 014001; KEGG: sli:Slin_5465 ATP-dependent DNA helicase, RecQ family; PFAM: DEAD/DEAH box helicase domain protein; helicase domain protein; SMART: DEAD-like helicase; helicase domain protein; SPTR: ATP-dependent DNA helicase, RecQ family; TIGRFAM: ATP-dependent DNA helicase, RecQ family; manually curated; PFAM: Helicase conserved C-terminal domain; DEAD/DEAH box helicase; TIGRFAM: ATP-dependent DNA helicase, RecQ family.
  
 
 0.786
Lbys_0471
COGs: COG0514 Superfamily II DNA helicase; InterProIPR002121:IPR014021:IPR001650:IPR011545:IPR 018982:IPR014001:IPR006293:IPR018329; KEGG: dfe:Dfer_3602 ATP-dependent DNA helicase RecQ; PFAM: helicase domain protein; DEAD/DEAH box helicase domain protein; RQC domain; HRDC domain protein; SMART: DEAD-like helicase; helicase domain protein; HRDC domain protein; SPTR: ATP-dependent DNA helicase RecQ; TIGRFAM: ATP-dependent DNA helicase RecQ; ATP-dependent DNA helicase, RecQ family; PFAM: Helicase conserved C-terminal domain; RQC domain; HRDC domain; DEAD/DEAH box helicase; TIGRFAM: ATP-de [...]
  
 
 0.780
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
 
   
 0.615
nadE
NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
  
    0.606
Lbys_2823
Cell division protein FtsK/SpoIIIE; COGs: COG1674 DNA segregation ATPase FtsK/SpoIIIE and related protein; InterPro IPR002543:IPR018541; KEGG: sli:Slin_5855 cell divisionFtsK/SpoIIIE; PFAM: cell divisionFtsK/SpoIIIE; DNA translocase ftsK gamma; SPTR: Cell divisionFtsK/SpoIIIE; PFAM: Ftsk gamma domain; FtsK/SpoIIIE family.
  
 0.606
Lbys_2587
3'-5' exonuclease, PolB; InterPro IPR019288; KEGG: dfe:Dfer_3714 hypothetical protein; PFAM: 3'-5' exonuclease, PolB-like; SPTR: Putative uncharacterized protein; PFAM: Predicted 3'-5' exonuclease related to the exonuclease domain of PolB.
    
 
 0.601
Lbys_1590
Transcriptional regulator, AsnC family; COGs: COG1522 Transcriptional regulators; InterPro IPR019887:IPR000485:IPR019888:IPR019885; KEGG: sli:Slin_5348 transcriptional regulator, AsnC family; PFAM: Transcription regulator AsnC-type-like; SMART: Transcription regulator AsnC-type; SPTR: Transcriptional regulator, AsnC family; PFAM: MarR family; AsnC family.
      0.590
Lbys_3529
KEGG: rmr:Rmar_1611 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.554
Lbys_3530
COGs: COG0667 oxidoreductase (related to aryl-alcohol dehydrogenase); InterPro IPR005399:IPR001395; KEGG: pdi:BDI_1188 putative oxidoreductase; PFAM: aldo/keto reductase; SPTR: Putative uncharacterized protein; PFAM: Aldo/keto reductase family.
       0.554
Your Current Organism:
Leadbetterella byssophila
NCBI taxonomy Id: 649349
Other names: L. byssophila DSM 17132, Leadbetterella byssophila 4M15, Leadbetterella byssophila DSM 17132, Leadbetterella byssophila str. DSM 17132, Leadbetterella byssophila strain DSM 17132
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