STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Lbys_3592COGs: COG0183 Acetyl-CoA acetyltransferase; InterProIPR020610:IPR020613:IPR020616:IPR020617:IPR 002155; KEGG: dfe:Dfer_2430 acetyl-CoA acetyltransferase; PFAM: Thiolase-like; PRIAM: Acetyl-CoA C-acetyltransferase; SPTR: Acetyl-CoA acetyltransferase; TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase, C-terminal domain; Thiolase, N-terminal domain; TIGRFAM: acetyl-CoA acetyltransferases; Belongs to the thiolase-like superfamily. Thiolase family. (392 aa)    
Predicted Functional Partners:
Lbys_2827
COGs: COG1250 3-hydroxyacyl-CoA dehydrogenase; InterPro IPR006176:IPR006108:IPR001753; KEGG: sli:Slin_4424 3-hydroxyacyl-CoA dehydrogenase NAD-binding protein; PFAM: 3-hydroxyacyl-CoA dehydrogenase NAD-binding; 3-hydroxyacyl-CoA dehydrogenase domain-containing protein; Enoyl-CoA hydratase/isomerase; SPTR: 3-hydroxyacyl-CoA dehydrogenase NAD-binding protein; PFAM: Enoyl-CoA hydratase/isomerase family; 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain.
 
 0.999
Lbys_3325
COGs: COG0372 Citrate synthase; InterPro IPR019810:IPR002020:IPR010953; KEGG: dfe:Dfer_0554 citrate synthase I; PFAM: Citrate synthase; PRIAM: Citrate (Si)-synthase; SPTR: Citrate synthase; TIGRFAM: citrate synthase I; PFAM: Citrate synthase; TIGRFAM: citrate (Si)-synthase, eukaryotic; citrate synthase I (hexameric type); Belongs to the citrate synthase family.
  
 0.948
Lbys_2963
acetoacetyl-CoA synthase; COGs: COG0365 Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase; InterPro IPR000873:IPR005914:IPR020845; KEGG: dfe:Dfer_3920 acetoacetyl-CoA synthase; PFAM: AMP-dependent synthetase and ligase; SPTR: Acetoacetate--CoA ligase; TIGRFAM: acetoacetyl-CoA synthase; PFAM: AMP-binding enzyme; TIGRFAM: acetoacetyl-CoA synthase.
  
 
 0.925
Lbys_3134
Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
  
 
 0.925
Lbys_2027
2-isopropylmalate synthase; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR002034:IPR000891; KEGG: sli:Slin_5897 pyruvate carboxyltransferase; PFAM: pyruvate carboxyltransferase; SPTR: Pyruvate carboxyltransferase; PFAM: HMGL-like; Belongs to the alpha-IPM synthase/homocitrate synthase family.
  
 
 0.924
Lbys_2972
Hydroxymethylglutaryl-CoA lyase; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR000891:IPR006162; KEGG: gfo:GFO_2517 hydroxymethylglutaryl-CoA lyase-like protein; PFAM: pyruvate carboxyltransferase; PRIAM: Hydroxymethylglutaryl-CoA lyase; SPTR: Hydroxymethylglutaryl-CoA lyase like protein; PFAM: HMGL-like.
  
 
 0.924
Lbys_1257
Succinate CoA transferase; COGs: COG0427 Acetyl-CoA hydrolase; InterPro IPR003702:IPR017821; KEGG: bba:Bd1620 acetyl-CoA hydrolase/transferase family protein; PFAM: acetyl-CoA hydrolase/transferase; PRIAM: Acetyl-CoA hydrolase; SPTR: Acetyl-CoA hydrolase/transferase family protein; TIGRFAM: succinate CoA transferase; PFAM: Acetyl-CoA hydrolase/transferase N-terminal domain; Citrate lyase, alpha subunit (CitF); TIGRFAM: succinate CoA transferases.
  
 
 0.919
Lbys_1333
Catalytic domain-containing protein of components of various dehydrogenase complexes; COGs: COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide acyltransferase (E2) protein; InterPro IPR000089:IPR004167:IPR001078:IPR003016; KEGG: chu:CHU_1755 dihydrolipoyllysine-residue acetyltransferase (dihydrolipoamide S-acetyltransferase); PFAM: catalytic domain-containing protein of components of various dehydrogenase complexes; biotin/lipoyl attachment domain-containing protein; E3 binding domain protein; SPTR: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate [...]
  
 
 0.916
Lbys_2828
COGs: COG0183 Acetyl-CoA acetyltransferase; InterProIPR020615:IPR020610:IPR002155:IPR020616:IPR 020617; KEGG: dfe:Dfer_3553 acetyl-CoA acetyltransferase; PFAM: Thiolase-like; SPTR: Acetyl-CoA acetyltransferase; TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase, C-terminal domain; Thiolase, N-terminal domain; TIGRFAM: acetyl-CoA acetyltransferases; Belongs to the thiolase-like superfamily. Thiolase family.
  
  
 
0.916
Lbys_1689
acetyl-CoA carboxylase, biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
    
 0.912
Your Current Organism:
Leadbetterella byssophila
NCBI taxonomy Id: 649349
Other names: L. byssophila DSM 17132, Leadbetterella byssophila 4M15, Leadbetterella byssophila DSM 17132, Leadbetterella byssophila str. DSM 17132, Leadbetterella byssophila strain DSM 17132
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