STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Trad_0902uroporphyrin-III C-methyltransferase; COGs: COG0007 Uroporphyrinogen-III methylase; InterProIPR006366:IPR003043:IPR000878:IPR014777:IPR 014776; KEGG: rxy:Rxyl_1977 uroporphyrinogen-III C-methyltransferase / uroporphyrinogen-III synthase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: Q1AUK4 Uroporphyrinogen-III C-methyltransferase / uroporphyrinogen-III synthase; TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. (274 aa)    
Predicted Functional Partners:
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
 0.988
Trad_0335
Hydroxymethylbilane synthase; COGs: COG0181 Porphobilinogen deaminase; InterPro IPR000860; KEGG: ttj:TTHA0345 porphobilinogen deaminase; PFAM: Porphobilinogen deaminase; PRIAM: Hydroxymethylbilane synthase; SPTR: C1XR62 Hydroxymethylbilane synthase; PFAM: Porphobilinogen deaminase, C-terminal domain; Porphobilinogen deaminase, dipyromethane cofactor binding domain; TIGRFAM: porphobilinogen deaminase.
  
 0.976
Trad_0226
Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
 
 
 0.964
Trad_0901
Cobalamin (vitamin B12) biosynthesis CbiX protein; COGs: COG2138 conserved hypothetical protein; InterPro IPR002762; KEGG: hau:Haur_2923 cobalamin (vitamin B12) biosynthesis CbiX protein; PFAM: cobalamin (vitamin B12) biosynthesis CbiX protein; SPTR: A9B3I9 Cobalamin (Vitamin B12) biosynthesis CbiX protein; PFAM: CbiX.
 
  
 0.956
Trad_0904
Nitrite and sulphite reductase 4Fe-4S region; COGs: COG0155 Sulfite reductase beta subunit (hemoprotein); InterPro IPR006066:IPR005117:IPR006067; KEGG: chl:Chy400_0742 sulfite reductase (NADPH); PFAM: nitrite and sulphite reductase 4Fe-4S region; nitrite/sulfite reductase hemoprotein beta-component ferrodoxin domain protein; SPTR: C1XVF5 Sulfite reductase (NADPH) beta subunit; PFAM: Nitrite and sulphite reductase 4Fe-4S domain; Nitrite/Sulfite reductase ferredoxin-like half domain; TIGRFAM: ferredoxin-sulfite reductase.
 
  
 0.952
Trad_0905
Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite.
 
  
 0.945
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
    
 0.934
Trad_0225
Porphobilinogen synthase; COGs: COG0113 Delta-aminolevulinic acid dehydratase; InterPro IPR001731:IPR013785; KEGG: scl:sce0016 delta-aminolevulinic acid dehydratase; PFAM: delta-aminolevulinic acid dehydratase; PRIAM: Porphobilinogen synthase; SPTR: C1XV33 Delta-aminolevulinic acid dehydratase; PFAM: Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
 
  
 0.905
Trad_1460
FAD-dependent pyridine nucleotide-disulfide oxidoreductase; COGs: COG1251 NAD(P)H-nitrite reductase; InterPro IPR017941:IPR013027:IPR004099:IPR016156; KEGG: rmr:Rmar_0914 FAD-dependent pyridine nucleotide-disulphide oxidoreductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Rieske [2Fe-2S] iron-sulphur domain; SPTR: D0MH23 FAD-dependent pyridine nucleotide-disulphide oxidoreductase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Rieske [2Fe-2S] domain.
  
  
 0.880
hemA
Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
  
 0.859
Your Current Organism:
Truepera radiovictrix
NCBI taxonomy Id: 649638
Other names: T. radiovictrix DSM 17093, Truepera radiovictrix DSM 17093, Truepera radiovictrix RQ-24, Truepera radiovictrix str. DSM 17093, Truepera radiovictrix strain DSM 17093
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