STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
sucDsuccinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (312 aa)    
Predicted Functional Partners:
sucC
succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 0.999
Trad_0358
COGs: COG0479 Succinate dehydrogenase/fumarate reductase Fe-S protein subunit; InterProIPR017900:IPR017896:IPR009051:IPR001041:IPR 012675:IPR012285:IPR004489; KEGG: tth:TTC1089 succinate dehydrogenase iron-sulfur subunit; PRIAM: Succinate dehydrogenase; SPTR: Q72IP3 Succinate dehydrogenase iron-sulfur protein; TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein; TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein.
 0.992
Trad_0355
InterPro IPR014314; KEGG: dge:Dgeo_0889 succinate dehydrogenase, cytochrome b subunit; SPTR: C1XVW6 Succinate dehydrogenase subunit C; TIGRFAM: succinate dehydrogenase, cytochrome b556 subunit; PFAM: Succinate dehydrogenase/Fumarate reductase transmembrane subunit; TIGRFAM: succinate dehydrogenase, cytochrome b556 subunit.
  
 
 0.984
Trad_0357
COGs: COG1053 Succinate dehydrogenase/fumarate reductase flavoprotein subunit; InterProIPR003952:IPR013027:IPR003953:IPR004112:IPR 015939:IPR011281:IPR014006; KEGG: ttj:TTHA1454 succinate dehydrogenase flavoprotein subunit; PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; SPTR: Q5SIC0 Succinate dehydrogenase, flavoprotein subunit; TIGRFAM: succinate dehydrogenase, flavoprotein subunit; succinate dehydrogenase or fumarate reductase, flavoprotein subunit; PFAM: domain; FAD binding domain; TIGRFAM: succinate dehydrogenase, flavoprotein subunit, E. coli/mitocho [...]
 0.984
Trad_0898
2-oxoglutarate dehydrogenase, E2 subunit, dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2).
 0.974
Trad_0897
COGs: COG0567 2-oxoglutarate dehydrogenase complex dehydrogenase (E1); InterPro IPR011603:IPR001017:IPR005475; KEGG: hoh:Hoch_4994 2-oxoglutarate dehydrogenase, E1 subunit; PFAM: Transketolase central region; dehydrogenase E1 component; PRIAM: Oxoglutarate dehydrogenase (succinyl-transferring); SPTR: B9XMW8 2-oxoglutarate dehydrogenase, E1 subunit; TIGRFAM: 2-oxoglutarate dehydrogenase, E1 subunit; PFAM: Dehydrogenase E1 component; Transketolase, pyrimidine binding domain; TIGRFAM: 2-oxoglutarate dehydrogenase, E1 component.
 0.968
Trad_0356
Succinate dehydrogenase, membrane subunit (SdhD); COGs: COG2142 Succinate dehydrogenase hydrophobic anchor subunit; KEGG: ttj:TTHA1455 succinate dehydrogenase, membrane subunit (SdhD); SPTR: C1XVW5 Succinate dehydrogenase subunit D; PFAM: Succinate dehydrogenase/Fumarate reductase transmembrane subunit; TIGRFAM: succinate dehydrogenase, hydrophobic membrane anchor protein.
  
 
 0.945
Trad_0748
Catalytic domain of components of various dehydrogenase complexes; COGs: COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide acyltransferase (E2) protein; InterProIPR000089:IPR003016:IPR004167:IPR001078:IPR 011053; KEGG: tth:TTC1754 branched-chain alpha-keto acid dehydrogenase subunit E2; PFAM: catalytic domain of components of various dehydrogenase complexes; biotin/lipoyl attachment domain-containing protein; E3 binding domain protein; SPTR: C1XX74 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase component; PFAM: 2-oxoacid dehydrogena [...]
 
 0.935
Trad_2188
Catalytic domain of components of various dehydrogenase complexes; COGs: COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide acyltransferase (E2) protein; InterProIPR011053:IPR004167:IPR000089:IPR001078:IPR 017441:IPR003016; KEGG: dra:DR_0256 pyruvate dehydrogenase complex, dihydrolipoamide acetyltransferase E2 component; PFAM: catalytic domain of components of various dehydrogenase complexes; biotin/lipoyl attachment domain-containing protein; E3 binding domain protein; SPTR: C1XL93 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase comp [...]
 
 0.934
Trad_1711
Cobalamin B12-binding domain protein; COGs: COG2185 Methylmalonyl-CoA mutase C-terminal domain/subunit (cobalamin-binding); InterPro IPR006158:IPR006159; KEGG: ttj:TTHA1038 methylmalonyl-CoA mutase, alpha subunit, chain B; PFAM: cobalamin B12-binding domain protein; SPTR: Q72JU2 Methylmalonyl-CoA mutase small subunit; PFAM: B12 binding domain; TIGRFAM: methylmalonyl-CoA mutase C-terminal domain.
    
 0.923
Your Current Organism:
Truepera radiovictrix
NCBI taxonomy Id: 649638
Other names: T. radiovictrix DSM 17093, Truepera radiovictrix DSM 17093, Truepera radiovictrix RQ-24, Truepera radiovictrix str. DSM 17093, Truepera radiovictrix strain DSM 17093
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