Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ADU31448.1TIGRFAM: primosome, DnaD subunit; KEGG: bha:BH3145 chromosome replication initiation/membrane attachment protein. (491 aa)    
Predicted Functional Partners:
ADU31447.1
KEGG: primosomal DnaI domain protein; PFAM: Primosomal DnaI domain protein; IstB domain protein ATP-binding protein; SMART: AAA ATPase.
 
  
 0.984
nrdR
ATP-cone domain protein; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family.
  
  
 0.910
ADU30175.1
TIGRFAM: primosome, DnaD subunit; KEGG: gwc:GWCH70_2110 primosome, DnaD subunit.
  
   
 0.847
ADU28715.1
PFAM: CamS sex pheromone cAM373 family protein; KEGG: CamS sex pheromone cAM373 family protein.
  
  
 0.815
ADU30866.1
PFAM: protein of unknown function DUF177; KEGG: protein of unknown function DUF177.
 
     0.800
ezrA
Septation ring formation regulator EzrA; Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization; Belongs to the EzrA family.
  
     0.753
ADU31450.1
KEGG: hypothetical protein.
       0.747
ADU31284.1
KEGG: rod shape-determining protein MreD; TIGRFAM: rod shape-determining protein MreD; PFAM: Rod shape-determining protein MreD.
 
     0.737
ADU30467.1
DivIVA domain; Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation.
  
     0.736
ADU28294.1
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
  
   
 0.714
Your Current Organism:
Bacillus cellulosilyticus
NCBI taxonomy Id: 649639
Other names: B. cellulosilyticus DSM 2522, Bacillus cellulosilyticus DSM 2522, Bacillus cellulosilyticus str. DSM 2522, Bacillus cellulosilyticus strain DSM 2522, Bacillus sp. (STRAIN N-4), Bacillus sp. ATCC 21833, Bacillus sp. N-4
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