STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ERI10502.1Hydrolyase, tartrate alpha subunit/fumarate domain protein, Fe-S type; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (509 aa)    
Predicted Functional Partners:
ERI08168.1
KEGG: bbe:BBR47_16840 5.6e-277 sdhA; succinate dehydrogenase flavoprotein subunit K00239; Psort location: Cytoplasmic, score: 9.89.
  
 
 0.999
mdh
Malate dehydrogenase, NAD-dependent; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family.
  
 
 0.998
gcvPB
Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily.
   
    0.992
ERI08613.1
Isocitrate dehydrogenase, NADP-dependent; KEGG: bbe:BBR47_13900 4.0e-196 icd; isocitrate dehydrogenase K00031; Psort location: Cytoplasmic, score: 9.97.
  
  
 0.992
ERI08167.1
KEGG: bbe:BBR47_16850 6.4e-111 sdhB; succinate dehydrogenase iron-sulfur subunit K00240; Psort location: Cytoplasmic, score: 9.89.
  
 
 0.991
ERI08612.1
Citrate synthase 2; KEGG: bbe:BBR47_13890 2.4e-136 citZ; citrate synthase K01647; Psort location: Cytoplasmic, score: 9.97.
  
 
 0.981
ERI08169.1
KEGG: bha:BH3093 1.8e-65 sdhC; succinate dehydrogenase cytochrome b-558 K00241; Psort location: CytoplasmicMembrane, score: 10.00.
  
 
 0.980
fumC
Fumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
  
 
 0.972
sucC
succinate-CoA ligase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 
 0.967
sucD
succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
  
 
 0.955
Your Current Organism:
Aneurinibacillus aneurinilyticus
NCBI taxonomy Id: 649747
Other names: A. aneurinilyticus ATCC 12856, Aneurinibacillus aneurinilyticus ATCC 12856, Aneurinibacillus aneurinilyticus DSM 5562, Aneurinibacillus aneurinilyticus str. ATCC 12856, Aneurinibacillus aneurinilyticus strain ATCC 12856
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