STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
trpBTryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (397 aa)    
Predicted Functional Partners:
trpA
Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
 0.999
trpC
KEGG: bbe:BBR47_24750 2.5e-61 trpC; indole-3-glycerol phosphate synthase K01609; Psort location: Cytoplasmic, score: 7.50; Belongs to the TrpC family.
 
 0.997
trpF
KEGG: ppo:PPM_2927 2.4e-47 trpF; N-(5'-phosphoribosyl)anthranilate isomerase PRAI K01817; Psort location: Cytoplasmic, score: 7.50; Belongs to the TrpF family.
 
 0.992
trpD
Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA).
 
 
 0.962
ERI09541.1
KEGG: gym:GYMC10_2608 1.2e-82 Anthranilate phosphoribosyltransferase K00766; Psort location: Cytoplasmic, score: 7.50.
 
 
 0.955
ERI08743.1
KEGG: bbe:BBR47_01720 1.5e-77 pabA; para-aminobenzoate/anthranilate synthase glutamine amidotransferase component II; K01664 para-aminobenzoate synthetase component II; Psort location: Cytoplasmic, score: 9.97.
 
 
 0.949
trpE
Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...]
 
  
 0.927
ERI08744.1
KEGG: bbe:BBR47_01710 1.4e-124 pabB; para-aminobenzoate synthase component I; K01665 para-aminobenzoate synthetase component I; Psort location: Cytoplasmic, score: 9.97.
 
  
 0.915
trpB-2
Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
  
  
 
0.877
ilvA
Threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
  
0.846
Your Current Organism:
Aneurinibacillus aneurinilyticus
NCBI taxonomy Id: 649747
Other names: A. aneurinilyticus ATCC 12856, Aneurinibacillus aneurinilyticus ATCC 12856, Aneurinibacillus aneurinilyticus DSM 5562, Aneurinibacillus aneurinilyticus str. ATCC 12856, Aneurinibacillus aneurinilyticus strain ATCC 12856
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