Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
guaAGMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. (530 aa)    
Predicted Functional Partners:
EEZ61499.1
KEGG: lwe:lwe0114 9.9e-212 inosine-5-monophosphate dehydrogenase, putative K00088; Psort location: Cytoplasmic, score: 8.87.
 
 0.997
EEZ60515.1
KEGG: blo:BL1108 0. purL; phosphoribosylformylglycinamidine synthase K01952; Psort location: Cytoplasmic, score: 8.87.
  
  
 0.963
EEZ61396.1
Drug resistance MFS transporter, drug:H+ antiporter-2 family; KEGG: sgl:SG1466 1.3e-06 dethiobiotin synthase K01935; Psort location: CytoplasmicMembrane, score: 10.00; Belongs to the major facilitator superfamily.
  
 
 0.957
apt
Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
  
 0.957
rpoC
DNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
  
  
 0.955
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
 
 
 0.954
hisA
KEGG: syc:syc2265_c 1.3e-49 hisA; phosphorybosilformimino-5-amino- phosphorybosil-4-imidazolecarboxamideisomerase K01814; Psort location: Cytoplasmic, score: 9.98.
  
 
 0.939
argS
arginine--tRNA ligase; KEGG: oih:OB3015 1.1e-125 argS; arginyl-tRNA synthetase K01887; Psort location: Cytoplasmic, score: 9.98.
   
  
 0.935
pyrD
Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate.
  
 0.927
rdgB
Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
 
 
 0.923
Your Current Organism:
Slackia exigua
NCBI taxonomy Id: 649764
Other names: S. exigua ATCC 700122, Slackia exigua ATCC 700122, Slackia exigua str. ATCC 700122, Slackia exigua strain ATCC 700122
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