STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EEZ61499.1KEGG: lwe:lwe0114 9.9e-212 inosine-5-monophosphate dehydrogenase, putative K00088; Psort location: Cytoplasmic, score: 8.87. (506 aa)    
Predicted Functional Partners:
guaA
GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP.
 
 0.998
purA
Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
  
 
 0.976
purH
Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; KEGG: gme:Gmet_2905 1.3e-140 AICARFT/IMPCHase bienzyme:MGS-like K00602:K01492; Psort location: Cytoplasmic, score: 8.87.
  
 
 0.950
EEZ62274.1
CBS domain protein; KEGG: mta:Moth_2414 2.8e-65 inorganic diphosphatase K01507; Psort location: Cytoplasmic, score: 8.87.
 
 
 0.941
hpt
KEGG: mle:ML0214 2.8e-49 hpt; putative hypoxanthine phosphoribosyltransferase K00760; Psort location: Cytoplasmic, score: 9.98; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
    
 0.927
rdgB
Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
  
 0.925
EEZ61396.1
Drug resistance MFS transporter, drug:H+ antiporter-2 family; KEGG: sgl:SG1466 1.3e-06 dethiobiotin synthase K01935; Psort location: CytoplasmicMembrane, score: 10.00; Belongs to the major facilitator superfamily.
  
 
 0.909
apt
Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
  
 
 0.873
EEZ62106.1
Hypothetical protein; KEGG: eci:UTI89_C1627 2.7e-13 entS; EntS/YbdA MFS transporter; Psort location: Cellwall, score: 9.17.
    
  0.818
EEZ60515.1
KEGG: blo:BL1108 0. purL; phosphoribosylformylglycinamidine synthase K01952; Psort location: Cytoplasmic, score: 8.87.
 
  
 0.813
Your Current Organism:
Slackia exigua
NCBI taxonomy Id: 649764
Other names: S. exigua ATCC 700122, Slackia exigua ATCC 700122, Slackia exigua str. ATCC 700122, Slackia exigua strain ATCC 700122
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.