STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (353 aa)    
Predicted Functional Partners:
leuD
3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily.
 
 0.999
leuC
3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 0.999
ilvN
KEGG: mma:MM0669 5.0e-43 acetolactate synthase small subunit K01653; Psort location: Cytoplasmic, score: 8.87.
  
 0.975
ilvB
Acetolactate synthase, large subunit, biosynthetic type; KEGG: mba:Mbar_A0218 4.9e-155 acetolactate synthase large subunit K01652; Psort location: Cytoplasmic, score: 8.87.
 
 0.961
leuA
Putative 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
  
 0.952
nifJ
KEGG: ctc:CTC01741 0. pyruvate-flavodoxin oxidoreductase K03737.
     
 0.920
EEZ60862.1
Isocitrate dehydrogenase, NADP-dependent; KEGG: tte:TTE0387 2.6e-149 icd; Isocitrate dehydrogenases K00031; Psort location: Cytoplasmic, score: 8.87; Belongs to the isocitrate and isopropylmalate dehydrogenases family.
  
 0.899
EEZ61978.1
Pyridine nucleotide-disulfide oxidoreductase; KEGG: cte:CT0282 1.2e-73 glutamate synthase (NADPH) small chain K00266; Psort location: Cytoplasmic, score: 9.98.
 
 0.886
ilvD
KEGG: tte:TTE0020 9.6e-182 ilvD; dihydroxy-acid dehydratase K01687; Psort location: Cytoplasmic, score: 8.87; Belongs to the IlvD/Edd family.
 
  
 0.877
ilvA
KEGG: fnu:FN1411 1.3e-113 threonine dehydratase K01754; Psort location: Cytoplasmic, score: 8.87.
  
 
 0.865
Your Current Organism:
Slackia exigua
NCBI taxonomy Id: 649764
Other names: S. exigua ATCC 700122, Slackia exigua ATCC 700122, Slackia exigua str. ATCC 700122, Slackia exigua strain ATCC 700122
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.