STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Cooccurrence
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[Homology]
Score
hisEphosphoribosyl-ATP diphosphatase; KEGG: bha:BH3577 1.2e-55 hisI; phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphohydrolase K01496:K01523; Psort location: Cytoplasmic, score: 9.98; In the N-terminal section; belongs to the PRA-CH family. (218 aa)    
Predicted Functional Partners:
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
 
 0.999
hisF
Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
  
 0.999
hisA
KEGG: syc:syc2265_c 1.3e-49 hisA; phosphorybosilformimino-5-amino- phosphorybosil-4-imidazolecarboxamideisomerase K01814; Psort location: Cytoplasmic, score: 9.98.
 
 0.999
hisH
Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
 
 
 0.999
hisB
KEGG: mta:Moth_2034 4.3e-53 imidazoleglycerol-phosphate dehydratase K01693; Psort location: Cytoplasmic, score: 8.87.
 
 
 0.999
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
 
 
 0.999
EEZ60650.1
Hypothetical protein; KEGG: swo:Swol_1770 3.4e-21 histidine--tRNA ligase K01891; Psort location: Cytoplasmic, score: 8.87.
 
 
 0.999
hisC
Putative histidinol-phosphate transaminase; KEGG: dar:Daro_3383 4.8e-77 histidinol-phosphate aminotransferase K00817; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
 
  
 0.994
EEZ60642.1
Histidinol phosphate phosphatase HisJ family; KEGG: bth:BT1478 4.0e-18 putative histidinol-phosphatase K04486; Psort location: Cytoplasmic, score: 8.87; Belongs to the PHP hydrolase family. HisK subfamily.
 
 
 0.958
EEZ61281.1
HAD hydrolase, family IB; KEGG: rha:RHA1_ro02056 2.3e-15 possible phosphoserine phosphatase K01079; Psort location: Cytoplasmic, score: 8.87.
  
  
 0.947
Your Current Organism:
Slackia exigua
NCBI taxonomy Id: 649764
Other names: S. exigua ATCC 700122, Slackia exigua ATCC 700122, Slackia exigua str. ATCC 700122, Slackia exigua strain ATCC 700122
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.