node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C3737_04730 | C3737_04735 | GCA_000813485_03388 | GCA_000813485_03389 | Unannotated protein. | Unannotated protein; Belongs to the Cob(I)alamin adenosyltransferase family. | 0.790 |
C3737_04730 | queC | GCA_000813485_03388 | GCA_000813485_03386 | Unannotated protein. | Unannotated protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.592 |
C3737_04730 | queE | GCA_000813485_03388 | GCA_000813485_03387 | Unannotated protein. | Unannotated protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.788 |
C3737_04735 | C3737_04730 | GCA_000813485_03389 | GCA_000813485_03388 | Unannotated protein; Belongs to the Cob(I)alamin adenosyltransferase family. | Unannotated protein. | 0.790 |
C3737_04735 | queC | GCA_000813485_03389 | GCA_000813485_03386 | Unannotated protein; Belongs to the Cob(I)alamin adenosyltransferase family. | Unannotated protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.617 |
C3737_04735 | queE | GCA_000813485_03389 | GCA_000813485_03387 | Unannotated protein; Belongs to the Cob(I)alamin adenosyltransferase family. | Unannotated protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.788 |
C3737_08755 | folE | GCA_000813485_01762 | GCA_000813485_00736 | Unannotated protein. | Unannotated protein. | 0.895 |
C3737_08755 | queC | GCA_000813485_01762 | GCA_000813485_03386 | Unannotated protein. | Unannotated protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.907 |
C3737_08755 | queE | GCA_000813485_01762 | GCA_000813485_03387 | Unannotated protein. | Unannotated protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.923 |
C3737_08755 | queF | GCA_000813485_01762 | GCA_000813485_04044 | Unannotated protein. | Unannotated protein; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.957 |
C3737_08755 | tgt | GCA_000813485_01762 | GCA_000813485_03305 | Unannotated protein. | Unannotated protein; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. [...] | 0.509 |
C3737_10825 | dut | GCA_000813485_01646 | GCA_000813485_03895 | Unannotated protein. | Unannotated protein; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.941 |
C3737_10825 | queE | GCA_000813485_01646 | GCA_000813485_03387 | Unannotated protein. | Unannotated protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.783 |
C3737_15050 | dut | GCA_000813485_01369 | GCA_000813485_03895 | Unannotated protein. | Unannotated protein; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.634 |
C3737_15050 | queE | GCA_000813485_01369 | GCA_000813485_03387 | Unannotated protein. | Unannotated protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.783 |
dut | C3737_10825 | GCA_000813485_03895 | GCA_000813485_01646 | Unannotated protein; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Unannotated protein. | 0.941 |
dut | C3737_15050 | GCA_000813485_03895 | GCA_000813485_01369 | Unannotated protein; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Unannotated protein. | 0.634 |
dut | queE | GCA_000813485_03895 | GCA_000813485_03387 | Unannotated protein; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Unannotated protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.579 |
dut | tgt | GCA_000813485_03895 | GCA_000813485_03305 | Unannotated protein; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Unannotated protein; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. [...] | 0.407 |
folE | C3737_08755 | GCA_000813485_00736 | GCA_000813485_01762 | Unannotated protein. | Unannotated protein. | 0.895 |