node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SFR56048.1 | trpB-2 | SAMN05216203_1380 | SAMN05216203_1379 | Hypothetical protein. | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.479 |
SFR74882.1 | SFR76051.1 | SAMN05216203_2741 | SAMN05216203_2839 | Homoserine dehydrogenase. | L-threonine ammonia-lyase. | 0.664 |
SFR74882.1 | glyA | SAMN05216203_2741 | SAMN05216203_3533 | Homoserine dehydrogenase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.606 |
SFR74882.1 | ilvA | SAMN05216203_2741 | SAMN05216203_1717 | Homoserine dehydrogenase. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.664 |
SFR74882.1 | trpA | SAMN05216203_2741 | SAMN05216203_0530 | Homoserine dehydrogenase. | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.652 |
SFR74882.1 | trpB | SAMN05216203_2741 | SAMN05216203_0531 | Homoserine dehydrogenase. | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.497 |
SFR74882.1 | trpB-2 | SAMN05216203_2741 | SAMN05216203_1379 | Homoserine dehydrogenase. | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.463 |
SFR74882.1 | trpF | SAMN05216203_2741 | SAMN05216203_0532 | Homoserine dehydrogenase. | Phosphoribosylanthranilate isomerase; Belongs to the TrpF family. | 0.498 |
SFR75172.1 | glyA | SAMN05216203_2768 | SAMN05216203_3533 | GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.470 |
SFR75172.1 | trpB | SAMN05216203_2768 | SAMN05216203_0531 | GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.402 |
SFR75172.1 | trpB-2 | SAMN05216203_2768 | SAMN05216203_1379 | GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.464 |
SFR76051.1 | SFR74882.1 | SAMN05216203_2839 | SAMN05216203_2741 | L-threonine ammonia-lyase. | Homoserine dehydrogenase. | 0.664 |
SFR76051.1 | glyA | SAMN05216203_2839 | SAMN05216203_3533 | L-threonine ammonia-lyase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.685 |
SFR76051.1 | trpA | SAMN05216203_2839 | SAMN05216203_0530 | L-threonine ammonia-lyase. | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.706 |
SFR76051.1 | trpB | SAMN05216203_2839 | SAMN05216203_0531 | L-threonine ammonia-lyase. | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.758 |
SFR76051.1 | trpB-2 | SAMN05216203_2839 | SAMN05216203_1379 | L-threonine ammonia-lyase. | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.568 |
SFR76051.1 | trpC | SAMN05216203_2839 | SAMN05216203_3241 | L-threonine ammonia-lyase. | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. | 0.520 |
SFR76051.1 | trpF | SAMN05216203_2839 | SAMN05216203_0532 | L-threonine ammonia-lyase. | Phosphoribosylanthranilate isomerase; Belongs to the TrpF family. | 0.507 |
glyA | SFR74882.1 | SAMN05216203_3533 | SAMN05216203_2741 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Homoserine dehydrogenase. | 0.606 |
glyA | SFR75172.1 | SAMN05216203_3533 | SAMN05216203_2768 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.470 |