STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AFZ42300.1PFAM: Histidine kinase; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; GAF domain; PAS fold; COGs: COG3920 Signal transduction histidine kinase; InterProIPR000014:IPR016132:IPR005467:IPR003018:IPR 013767:IPR011495:IPR003594; KEGG: cyn:Cyan7425_2336 signal transduction histidine kinase; PFAM: histidine kinase dimerisation/phosphoacceptor; GAF domain protein; PAS fold domain protein; ATP-binding region ATPase domain protein; SMART: GAF domain protein; PAS domain containing protein; ATP-binding region ATPase domain protein; SPTR: Two-component hybrid sensor and regulator; TIGRFA [...] (709 aa)    
Predicted Functional Partners:
AFZ42299.1
PFAM: Response regulator receiver domain; COGs: COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains; InterPro IPR001789; KEGG: gur:Gura_2117 putative PAS/PAC sensor protein; PFAM: response regulator receiver; SMART: response regulator receiver; SPTR: Two-component hybrid sensor and regulator.
 
 0.961
AFZ45918.1
PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; GAF domain; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR016132:IPR005467:IPR001789:IPR000014:IPR 000700:IPR003018:IPR013655:IPR013656:IPR013767:IPR003661:I PR003594:IPR004358:IPR001610; KEGG: ava:Ava_4701 multi-sensor hybrid histidine kinase; PFAM: ATP-binding region ATPase domain protein; PAS fold-3 domain protein; GAF domain protein; PAS fold-4 domain protein; PAS fold domain protein; histidin [...]
   
 
0.924
AFZ45080.1
PFAM: CBS domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; GAF domain; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; Hpt domain; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR004358:IPR017871:IPR000644:IPR003018:IPR 003661:IPR003594:IPR001789:IPR008207:IPR000014:IPR005467:I PR000700; KEGG: npu:Npun_F2363 multi-sensor hybrid histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; CBS domain containing protein; GAF domain protein; response regulator receiv [...]
  
 
 0.923
AFZ43253.1
PFAM: HAMP domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; GAF domain; His Kinase A (phosphoacceptor) domain; PAS fold; Hpt domain; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR000014:IPR005467:IPR001789:IPR000700:IPR 008207:IPR003018:IPR003661:IPR003594:IPR004358:IPR003660:I PR013656; KEGG: ana:all2875 two-component hybrid sensor and regulator; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold-4 domain protein; histidine kinase HAMP region domain [...]
 
 
 
 0.921
AFZ43901.1
PFAM: CBS domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR000644:IPR000014:IPR001610:IPR003661:IPR 003594:IPR001789:IPR005467:IPR000700:IPR013656:IPR013655:I PR013767:IPR004358; KEGG: ana:all4097 two-component hybrid sensor and regulator; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold-3 domain protein; PAS fold-4 domain protein; CBS domain containing pr [...]
 
 
 0.890
AFZ44863.1
PFAM: HAMP domain; Cache domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; Hpt domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR005467:IPR001789:IPR000014:IPR000700:IPR 003660:IPR008207:IPR001610:IPR003661:IPR003594:IPR004010:I PR013656:IPR013655:IPR004358; KEGG: hch:HCH_00809 signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold-4 domain protein; histidine kinase [...]
 
 
0.868
AFZ43648.1
Diguanylate cyclase/phosphodiesterase with GAF sensor; PFAM: EAL domain; GGDEF domain; GAF domain; Phytochrome region; TIGRFAM: diguanylate cyclase (GGDEF) domain; COGs: COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain; InterPro IPR016132:IPR001633:IPR000160:IPR003018; KEGG: cyc:PCC7424_3673 diguanylate cyclase/phosphodiesterase with GAF sensor; PFAM: EAL domain protein; GGDEF domain containing protein; GAF domain protein; SMART: EAL domain protein; GGDEF domain containing protein; GAF domain protein; SPTR: Diguanylate cyclase/phosphodiesterase [...]
  
 
0.862
AFZ44992.1
PFAM: Response regulator receiver domain; COGs: COG0784 FOG: CheY-like receiver; InterPro IPR001789; KEGG: dsa:Desal_3678 putative PAS/PAC sensor protein; PFAM: response regulator receiver; SMART: response regulator receiver; SPTR: Putative PAS/PAC sensor protein.
 
 0.851
AFZ43781.1
PFAM: Response regulator receiver domain; COGs: COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; InterPro IPR001789; KEGG: cyb:CYB_1654 response regulator; PFAM: response regulator receiver; SMART: response regulator receiver; SPTR: Response Regulator Receiver Signal Transduction Histidine Kinase.
 
 0.845
AFZ44510.1
Multi-sensor signal transduction histidine kinase; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; GAF domain; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR005467:IPR001789:IPR000014:IPR000700:IPR 013655:IPR003018:IPR003661:IPR003594:IPR004358:IPR001610; KEGG: npu:Npun_F5679 multi-sensor hybrid multi-kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; response regulator receiver; PAS fold-3 domain protein [...]
   
 
 0.774
Your Current Organism:
Halothece sp. PCC7418
NCBI taxonomy Id: 65093
Other names: Aphanothece halophytica 7418, Cyanothece sp. PCC 7418, H. sp. PCC 7418, Halothece sp. PCC 7418, Synechococcus sp. ATCC 29534 (no longer available), Synechococcus sp. PCC 7418
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.