node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AFZ42982.1 | AFZ43844.1 | PCC7418_0763 | PCC7418_1665 | PFAM: Aminotransferase class IV; COGs: COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; InterPro IPR001544; KEGG: cyc:PCC7424_3756 aminotransferase class IV; PFAM: aminotransferase class IV; SPTR: Aminotransferase class IV. | Valine-pyruvate aminotransferase apoenzyme; PFAM: Aminotransferase class I and II; COGs: COG3977 Alanine-alpha-ketoisovalerate (or valine-pyruvate) aminotransferase; InterPro IPR004839; KEGG: ava:Ava_1090 valine--pyruvate transaminase; PFAM: aminotransferase class I and II; SPTR: Aminotransferase, class I and II. | 0.919 |
AFZ42982.1 | AFZ44340.1 | PCC7418_0763 | PCC7418_2181 | PFAM: Aminotransferase class IV; COGs: COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; InterPro IPR001544; KEGG: cyc:PCC7424_3756 aminotransferase class IV; PFAM: aminotransferase class IV; SPTR: Aminotransferase class IV. | PFAM: LeuA allosteric (dimerisation) domain; HMGL-like; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR005675:IPR000891:IPR002034:IPR013709; KEGG: cyh:Cyan8802_0462 putative alpha-isopropylmalate/homocitrate synthase family transferase; PFAM: LeuA allosteric (dimerisation) domain-containing protein; pyruvate carboxyltransferase; SPTR: 2-isopropylmalate synthase/homocitrate synthase family protein; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; Belongs to the a [...] | 0.974 |
AFZ42982.1 | AFZ44844.1 | PCC7418_0763 | PCC7418_2706 | PFAM: Aminotransferase class IV; COGs: COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; InterPro IPR001544; KEGG: cyc:PCC7424_3756 aminotransferase class IV; PFAM: aminotransferase class IV; SPTR: Aminotransferase class IV. | Acetolactate synthase, large subunit; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterPro IPR012001:IPR012000:IPR011766:IPR000399; KEGG: syp:SYNPCC7002_A2770 acetolactate synthase; PFAM: thiamine pyrophosphate TPP-binding domain-containing protein; thiamine pyrophosphate central domain-containing protein; SPTR: Acetolactate synthase. | 0.598 |
AFZ42982.1 | AFZ45598.1 | PCC7418_0763 | PCC7418_3486 | PFAM: Aminotransferase class IV; COGs: COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; InterPro IPR001544; KEGG: cyc:PCC7424_3756 aminotransferase class IV; PFAM: aminotransferase class IV; SPTR: Aminotransferase class IV. | Acetolactate synthase, large subunit; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterPro IPR012846:IPR012001:IPR012000:IPR011766; KEGG: cyh:Cyan8802_0929 acetolactate synthase 3 catalytic subunit; PFAM: thiamine pyrophosphate TPP-binding domain-containing protein; thiamine pyrophosphate central domain-containing protein; SPTR: Acetol [...] | 0.598 |
AFZ42982.1 | ilvC | PCC7418_0763 | PCC7418_0093 | PFAM: Aminotransferase class IV; COGs: COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; InterPro IPR001544; KEGG: cyc:PCC7424_3756 aminotransferase class IV; PFAM: aminotransferase class IV; SPTR: Aminotransferase class IV. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.529 |
AFZ42982.1 | ilvD | PCC7418_0763 | PCC7418_1767 | PFAM: Aminotransferase class IV; COGs: COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; InterPro IPR001544; KEGG: cyc:PCC7424_3756 aminotransferase class IV; PFAM: aminotransferase class IV; SPTR: Aminotransferase class IV. | PFAM: Dehydratase family; TIGRFAM: dihydroxy-acid dehydratase; COGs: COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; InterPro IPR002114:IPR020558:IPR000581:IPR004404; KEGG: cyc:PCC7424_2821 dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; PRIAM: Dihydroxy-acid dehydratase; SPTR: Dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.987 |
AFZ42982.1 | leuA | PCC7418_0763 | PCC7418_3243 | PFAM: Aminotransferase class IV; COGs: COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; InterPro IPR001544; KEGG: cyc:PCC7424_3756 aminotransferase class IV; PFAM: aminotransferase class IV; SPTR: Aminotransferase class IV. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.974 |
AFZ42982.1 | leuC | PCC7418_0763 | PCC7418_3114 | PFAM: Aminotransferase class IV; COGs: COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; InterPro IPR001544; KEGG: cyc:PCC7424_3756 aminotransferase class IV; PFAM: aminotransferase class IV; SPTR: Aminotransferase class IV. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.546 |
AFZ42982.1 | panB | PCC7418_0763 | PCC7418_0142 | PFAM: Aminotransferase class IV; COGs: COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; InterPro IPR001544; KEGG: cyc:PCC7424_3756 aminotransferase class IV; PFAM: aminotransferase class IV; SPTR: Aminotransferase class IV. | Ketopantoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.926 |
AFZ43844.1 | AFZ42982.1 | PCC7418_1665 | PCC7418_0763 | Valine-pyruvate aminotransferase apoenzyme; PFAM: Aminotransferase class I and II; COGs: COG3977 Alanine-alpha-ketoisovalerate (or valine-pyruvate) aminotransferase; InterPro IPR004839; KEGG: ava:Ava_1090 valine--pyruvate transaminase; PFAM: aminotransferase class I and II; SPTR: Aminotransferase, class I and II. | PFAM: Aminotransferase class IV; COGs: COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; InterPro IPR001544; KEGG: cyc:PCC7424_3756 aminotransferase class IV; PFAM: aminotransferase class IV; SPTR: Aminotransferase class IV. | 0.919 |
AFZ43844.1 | AFZ44340.1 | PCC7418_1665 | PCC7418_2181 | Valine-pyruvate aminotransferase apoenzyme; PFAM: Aminotransferase class I and II; COGs: COG3977 Alanine-alpha-ketoisovalerate (or valine-pyruvate) aminotransferase; InterPro IPR004839; KEGG: ava:Ava_1090 valine--pyruvate transaminase; PFAM: aminotransferase class I and II; SPTR: Aminotransferase, class I and II. | PFAM: LeuA allosteric (dimerisation) domain; HMGL-like; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR005675:IPR000891:IPR002034:IPR013709; KEGG: cyh:Cyan8802_0462 putative alpha-isopropylmalate/homocitrate synthase family transferase; PFAM: LeuA allosteric (dimerisation) domain-containing protein; pyruvate carboxyltransferase; SPTR: 2-isopropylmalate synthase/homocitrate synthase family protein; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; Belongs to the a [...] | 0.900 |
AFZ43844.1 | ilvD | PCC7418_1665 | PCC7418_1767 | Valine-pyruvate aminotransferase apoenzyme; PFAM: Aminotransferase class I and II; COGs: COG3977 Alanine-alpha-ketoisovalerate (or valine-pyruvate) aminotransferase; InterPro IPR004839; KEGG: ava:Ava_1090 valine--pyruvate transaminase; PFAM: aminotransferase class I and II; SPTR: Aminotransferase, class I and II. | PFAM: Dehydratase family; TIGRFAM: dihydroxy-acid dehydratase; COGs: COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; InterPro IPR002114:IPR020558:IPR000581:IPR004404; KEGG: cyc:PCC7424_2821 dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; PRIAM: Dihydroxy-acid dehydratase; SPTR: Dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.912 |
AFZ43844.1 | leuA | PCC7418_1665 | PCC7418_3243 | Valine-pyruvate aminotransferase apoenzyme; PFAM: Aminotransferase class I and II; COGs: COG3977 Alanine-alpha-ketoisovalerate (or valine-pyruvate) aminotransferase; InterPro IPR004839; KEGG: ava:Ava_1090 valine--pyruvate transaminase; PFAM: aminotransferase class I and II; SPTR: Aminotransferase, class I and II. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.900 |
AFZ44340.1 | AFZ42982.1 | PCC7418_2181 | PCC7418_0763 | PFAM: LeuA allosteric (dimerisation) domain; HMGL-like; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR005675:IPR000891:IPR002034:IPR013709; KEGG: cyh:Cyan8802_0462 putative alpha-isopropylmalate/homocitrate synthase family transferase; PFAM: LeuA allosteric (dimerisation) domain-containing protein; pyruvate carboxyltransferase; SPTR: 2-isopropylmalate synthase/homocitrate synthase family protein; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; Belongs to the a [...] | PFAM: Aminotransferase class IV; COGs: COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; InterPro IPR001544; KEGG: cyc:PCC7424_3756 aminotransferase class IV; PFAM: aminotransferase class IV; SPTR: Aminotransferase class IV. | 0.974 |
AFZ44340.1 | AFZ43844.1 | PCC7418_2181 | PCC7418_1665 | PFAM: LeuA allosteric (dimerisation) domain; HMGL-like; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR005675:IPR000891:IPR002034:IPR013709; KEGG: cyh:Cyan8802_0462 putative alpha-isopropylmalate/homocitrate synthase family transferase; PFAM: LeuA allosteric (dimerisation) domain-containing protein; pyruvate carboxyltransferase; SPTR: 2-isopropylmalate synthase/homocitrate synthase family protein; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; Belongs to the a [...] | Valine-pyruvate aminotransferase apoenzyme; PFAM: Aminotransferase class I and II; COGs: COG3977 Alanine-alpha-ketoisovalerate (or valine-pyruvate) aminotransferase; InterPro IPR004839; KEGG: ava:Ava_1090 valine--pyruvate transaminase; PFAM: aminotransferase class I and II; SPTR: Aminotransferase, class I and II. | 0.900 |
AFZ44340.1 | AFZ44844.1 | PCC7418_2181 | PCC7418_2706 | PFAM: LeuA allosteric (dimerisation) domain; HMGL-like; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR005675:IPR000891:IPR002034:IPR013709; KEGG: cyh:Cyan8802_0462 putative alpha-isopropylmalate/homocitrate synthase family transferase; PFAM: LeuA allosteric (dimerisation) domain-containing protein; pyruvate carboxyltransferase; SPTR: 2-isopropylmalate synthase/homocitrate synthase family protein; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; Belongs to the a [...] | Acetolactate synthase, large subunit; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterPro IPR012001:IPR012000:IPR011766:IPR000399; KEGG: syp:SYNPCC7002_A2770 acetolactate synthase; PFAM: thiamine pyrophosphate TPP-binding domain-containing protein; thiamine pyrophosphate central domain-containing protein; SPTR: Acetolactate synthase. | 0.870 |
AFZ44340.1 | AFZ45598.1 | PCC7418_2181 | PCC7418_3486 | PFAM: LeuA allosteric (dimerisation) domain; HMGL-like; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR005675:IPR000891:IPR002034:IPR013709; KEGG: cyh:Cyan8802_0462 putative alpha-isopropylmalate/homocitrate synthase family transferase; PFAM: LeuA allosteric (dimerisation) domain-containing protein; pyruvate carboxyltransferase; SPTR: 2-isopropylmalate synthase/homocitrate synthase family protein; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; Belongs to the a [...] | Acetolactate synthase, large subunit; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterPro IPR012846:IPR012001:IPR012000:IPR011766; KEGG: cyh:Cyan8802_0929 acetolactate synthase 3 catalytic subunit; PFAM: thiamine pyrophosphate TPP-binding domain-containing protein; thiamine pyrophosphate central domain-containing protein; SPTR: Acetol [...] | 0.890 |
AFZ44340.1 | ilvC | PCC7418_2181 | PCC7418_0093 | PFAM: LeuA allosteric (dimerisation) domain; HMGL-like; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR005675:IPR000891:IPR002034:IPR013709; KEGG: cyh:Cyan8802_0462 putative alpha-isopropylmalate/homocitrate synthase family transferase; PFAM: LeuA allosteric (dimerisation) domain-containing protein; pyruvate carboxyltransferase; SPTR: 2-isopropylmalate synthase/homocitrate synthase family protein; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; Belongs to the a [...] | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.795 |
AFZ44340.1 | ilvD | PCC7418_2181 | PCC7418_1767 | PFAM: LeuA allosteric (dimerisation) domain; HMGL-like; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR005675:IPR000891:IPR002034:IPR013709; KEGG: cyh:Cyan8802_0462 putative alpha-isopropylmalate/homocitrate synthase family transferase; PFAM: LeuA allosteric (dimerisation) domain-containing protein; pyruvate carboxyltransferase; SPTR: 2-isopropylmalate synthase/homocitrate synthase family protein; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; Belongs to the a [...] | PFAM: Dehydratase family; TIGRFAM: dihydroxy-acid dehydratase; COGs: COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; InterPro IPR002114:IPR020558:IPR000581:IPR004404; KEGG: cyc:PCC7424_2821 dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; PRIAM: Dihydroxy-acid dehydratase; SPTR: Dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.972 |
AFZ44340.1 | leuA | PCC7418_2181 | PCC7418_3243 | PFAM: LeuA allosteric (dimerisation) domain; HMGL-like; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR005675:IPR000891:IPR002034:IPR013709; KEGG: cyh:Cyan8802_0462 putative alpha-isopropylmalate/homocitrate synthase family transferase; PFAM: LeuA allosteric (dimerisation) domain-containing protein; pyruvate carboxyltransferase; SPTR: 2-isopropylmalate synthase/homocitrate synthase family protein; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; Belongs to the a [...] | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.920 |