STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
AFZ44588.1Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(s); PFAM: EAL domain; GAF domain; GGDEF domain; PAS fold; TIGRFAM: PAS domain S-box; diguanylate cyclase (GGDEF) domain; COGs: COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain; InterProIPR000014:IPR000700:IPR001633:IPR000160:IPR 013656:IPR003018:IPR013767:IPR001610; KEGG: cyc:PCC7424_5136 response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); PFAM: EAL domain protein; GGDEF domain containing protein; PAS fold-4 domain protein; GAF doma [...] (953 aa)    
Predicted Functional Partners:
AFZ43253.1
PFAM: HAMP domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; GAF domain; His Kinase A (phosphoacceptor) domain; PAS fold; Hpt domain; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR000014:IPR005467:IPR001789:IPR000700:IPR 008207:IPR003018:IPR003661:IPR003594:IPR004358:IPR003660:I PR013656; KEGG: ana:all2875 two-component hybrid sensor and regulator; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold-4 domain protein; histidine kinase HAMP region domain [...]
 
0.994
AFZ45080.1
PFAM: CBS domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; GAF domain; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; Hpt domain; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR004358:IPR017871:IPR000644:IPR003018:IPR 003661:IPR003594:IPR001789:IPR008207:IPR000014:IPR005467:I PR000700; KEGG: npu:Npun_F2363 multi-sensor hybrid histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; CBS domain containing protein; GAF domain protein; response regulator receiv [...]
 
 0.994
AFZ44863.1
PFAM: HAMP domain; Cache domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; Hpt domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR005467:IPR001789:IPR000014:IPR000700:IPR 003660:IPR008207:IPR001610:IPR003661:IPR003594:IPR004010:I PR013656:IPR013655:IPR004358; KEGG: hch:HCH_00809 signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold-4 domain protein; histidine kinase [...]
 
0.989
AFZ43648.1
Diguanylate cyclase/phosphodiesterase with GAF sensor; PFAM: EAL domain; GGDEF domain; GAF domain; Phytochrome region; TIGRFAM: diguanylate cyclase (GGDEF) domain; COGs: COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain; InterPro IPR016132:IPR001633:IPR000160:IPR003018; KEGG: cyc:PCC7424_3673 diguanylate cyclase/phosphodiesterase with GAF sensor; PFAM: EAL domain protein; GGDEF domain containing protein; GAF domain protein; SMART: EAL domain protein; GGDEF domain containing protein; GAF domain protein; SPTR: Diguanylate cyclase/phosphodiesterase [...]
 
 
0.988
AFZ43901.1
PFAM: CBS domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR000644:IPR000014:IPR001610:IPR003661:IPR 003594:IPR001789:IPR005467:IPR000700:IPR013656:IPR013655:I PR013767:IPR004358; KEGG: ana:all4097 two-component hybrid sensor and regulator; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold-3 domain protein; PAS fold-4 domain protein; CBS domain containing pr [...]
 
 
0.964
AFZ44577.1
Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(s); PFAM: EAL domain; GAF domain; GGDEF domain; PAS fold; TIGRFAM: PAS domain S-box; diguanylate cyclase (GGDEF) domain; COGs: COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain; InterProIPR000014:IPR000700:IPR001633:IPR000160:IPR 003018:IPR013767:IPR001610:IPR010916; KEGG: cyn:Cyan7425_3275 diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); PFAM: EAL domain protein; GGDEF domain containing protein; GAF domain protein; PAS fold domain protein; SMART: EAL domain protein; [...]
 
 
0.963
AFZ45918.1
PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; GAF domain; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR016132:IPR005467:IPR001789:IPR000014:IPR 000700:IPR003018:IPR013655:IPR013656:IPR013767:IPR003661:I PR003594:IPR004358:IPR001610; KEGG: ava:Ava_4701 multi-sensor hybrid histidine kinase; PFAM: ATP-binding region ATPase domain protein; PAS fold-3 domain protein; GAF domain protein; PAS fold-4 domain protein; PAS fold domain protein; histidin [...]
 
 
0.961
AFZ42839.1
PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; Hpt domain; COGs: COG0642 Signal transduction histidine kinase; InterProIPR004358:IPR005467:IPR001789:IPR008207:IPR 003661:IPR003594; KEGG: cyb:CYB_0507 sensory box histidine kinase/response regulator; PFAM: ATP-binding region ATPase domain protein; response regulator receiver; histidine kinase A domain protein; Hpt domain protein; SMART: ATP-binding region ATPase domain protein; response regulator receiver; histidine kinase A domain protein; SPTR: P [...]
 
 0.954
AFZ44510.1
Multi-sensor signal transduction histidine kinase; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; GAF domain; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR005467:IPR001789:IPR000014:IPR000700:IPR 013655:IPR003018:IPR003661:IPR003594:IPR004358:IPR001610; KEGG: npu:Npun_F5679 multi-sensor hybrid multi-kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; response regulator receiver; PAS fold-3 domain protein [...]
 
 
 0.932
AFZ45909.1
Diguanylate cyclase with PAS/PAC and GAF sensors; PFAM: GAF domain; GGDEF domain; Bacterial extracellular solute-binding proteins, family 3; PAS fold; TIGRFAM: PAS domain S-box; diguanylate cyclase (GGDEF) domain; COGs: COG2199 FOG: GGDEF domain; InterProIPR016132:IPR000014:IPR000700:IPR000160:IPR 001638:IPR013655:IPR003018; KEGG: tel:tlr1999 hypothetical protein; PFAM: GGDEF domain containing protein; extracellular solute-binding protein family 3; PAS fold-3 domain protein; GAF domain protein; SMART: GGDEF domain containing protein; extracellular solute-binding protein family 3; GAF d [...]
 
 
0.928
Your Current Organism:
Halothece sp. PCC7418
NCBI taxonomy Id: 65093
Other names: Aphanothece halophytica 7418, Cyanothece sp. PCC 7418, H. sp. PCC 7418, Halothece sp. PCC 7418, Synechococcus sp. ATCC 29534 (no longer available), Synechococcus sp. PCC 7418
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