STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
cofHFO synthase subunit 2; Catalyzes the radical-mediated synthesis of 5-amino-5-(4- hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D- ribitylamino)uracil and L-tyrosine. (381 aa)    
Predicted Functional Partners:
cofG
FO synthase subunit 1; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D- ribitylimino)-5,6-dihydrouracil.
 
  
 0.999
thiG
Thiazole-phosphate synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
  
 
 0.868
thiC
Hydroxymethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.
  
  
 0.809
AFZ45687.1
Anti-sigma-factor antagonist; PFAM: STAS domain; TIGRFAM: anti-anti-sigma factor; COGs: COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor); InterPro IPR003658:IPR002645; KEGG: ava:Ava_4411 anti-sigma-factor antagonist domain-containing protein; PFAM: Sulfate transporter/antisigma-factor antagonist STAS; SPTR: Anti-sigma factor antagonist; TIGRFAM: anti-anti-sigma factor.
  
    0.775
AFZ42506.1
COGs: COG2172 Anti-sigma regulatory factor (Ser/Thr protein kinase); InterPro IPR016781; KEGG: naz:Aazo_3653 putative anti-sigma regulatory factor serine/threonine protein kinase; SPTR: Putative anti-sigma regulatory factor, serine/threonine protein kinase.
   
    0.772
AFZ45080.1
PFAM: CBS domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; GAF domain; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; Hpt domain; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR004358:IPR017871:IPR000644:IPR003018:IPR 003661:IPR003594:IPR001789:IPR008207:IPR000014:IPR005467:I PR000700; KEGG: npu:Npun_F2363 multi-sensor hybrid histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; CBS domain containing protein; GAF domain protein; response regulator receiv [...]
  
 
 0.738
AFZ44310.1
PFAM: ThiS family; TIGRFAM: thiamine biosynthesis protein ThiS; InterPro IPR010035:IPR003749; KEGG: ava:Ava_5046 hypothetical protein; PFAM: thiamineS protein; SPTR: ThiS, thiamine-biosynthesis; TIGRFAM: thiamine biosynthesis protein ThiS.
  
    0.728
AFZ43648.1
Diguanylate cyclase/phosphodiesterase with GAF sensor; PFAM: EAL domain; GGDEF domain; GAF domain; Phytochrome region; TIGRFAM: diguanylate cyclase (GGDEF) domain; COGs: COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain; InterPro IPR016132:IPR001633:IPR000160:IPR003018; KEGG: cyc:PCC7424_3673 diguanylate cyclase/phosphodiesterase with GAF sensor; PFAM: EAL domain protein; GGDEF domain containing protein; GAF domain protein; SMART: EAL domain protein; GGDEF domain containing protein; GAF domain protein; SPTR: Diguanylate cyclase/phosphodiesterase [...]
 
  
 0.727
thiE
Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
  
  
 0.716
AFZ45870.1
PFAM: Protein of unknown function (DUF561); InterPro IPR007570; KEGG: cyc:PCC7424_0284 protein of unknown function DUF561; PFAM: protein of unknown function DUF561; SPTR: Putative uncharacterized protein.
  
  
 0.716
Your Current Organism:
Halothece sp. PCC7418
NCBI taxonomy Id: 65093
Other names: Aphanothece halophytica 7418, Cyanothece sp. PCC 7418, H. sp. PCC 7418, Halothece sp. PCC 7418, Synechococcus sp. ATCC 29534 (no longer available), Synechococcus sp. PCC 7418
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