STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
pdhAPyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (344 aa)    
Predicted Functional Partners:
AFZ43325.1
Catalytic domain-containing protein of components of various dehydrogenase complexes; PFAM: 2-oxoacid dehydrogenases acyltransferase (catalytic domain); e3 binding domain; Biotin-requiring enzyme; TIGRFAM: pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; COGs: COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide acyltransferase (E2) protein; InterProIPR003016:IPR000276:IPR000089:IPR004167:IPR 001078; KEGG: cyh:Cyan8802_1261 branched-chain alpha-keto acid dehydrogenase subunit E2; PFAM: catalytic domain-containing protein of components of v [...]
 
 0.999
AFZ45860.1
Transketolase central region; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
 0.999
AFZ45577.1
Dihydrolipoamide dehydrogenase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; TIGRFAM: dihydrolipoamide dehydrogenase; COGs: COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3); InterProIPR006258:IPR013027:IPR004099:IPR000815:IPR 012999; KEGG: mar:MAE_50450 dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; SPTR: Dihydrolipoyl dehydrogenase; TIGRFAM: dihydrolipo [...]
 
 
 0.993
AFZ42794.1
Pyruvate ferredoxin/flavodoxin oxidoreductase; Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin.
    
 0.960
AFZ45345.1
PFAM: Pyruvate kinase, barrel domain; PEP-utilising enzyme, mobile domain; Pyruvate kinase, alpha/beta domain; TIGRFAM: pyruvate kinase; COGs: COG0469 Pyruvate kinase; InterProIPR015793:IPR018209:IPR001697:IPR015794:IPR 008279; KEGG: npu:Npun_F4277 pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; PEP-utilising protein mobile region; SPTR: Pyruvate kinase; TIGRFAM: pyruvate kinase; Belongs to the pyruvate kinase family.
  
 
 0.942
AFZ42763.1
PFAM: Glycine radical; Pyruvate formate lyase; TIGRFAM: formate acetyltransferase 1; COGs: COG1882 Pyruvate-formate lyase; InterPro IPR019777:IPR005949:IPR001150:IPR004184; KEGG: cyc:PCC7424_2838 formate acetyltransferase; PFAM: pyruvate formate-lyase PFL; formate C-acetyltransferase glycine radical; PRIAM: Formate C-acetyltransferase; SPTR: Formate acetyltransferase; TIGRFAM: formate acetyltransferase.
   
 
 0.932
AFZ45563.1
Pyridine nucleotide-disulfide oxidoreductase dimerization region; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; COGs: COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3); InterPro IPR013027:IPR004099:IPR000815; KEGG: cyp:PCC8801_3125 pyridine nucleotide-disulphide oxidoreductase dimerisation region; PFAM: pyridine nucleotide-disulphide oxidoreductase dimerisation region; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; SPTR: Pyridine nucleotide-disulphide oxidore [...]
 
 
 0.928
ldh
L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family.
   
 
 0.925
AFZ44813.1
Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)); PFAM: Malic enzyme, NAD binding domain; Malic enzyme, N-terminal domain; COGs: COG0281 Malic enzyme; InterPro IPR012301:IPR012302:IPR015884; KEGG: cyh:Cyan8802_3203 malate dehydrogenase (oxaloacetate-decarboxylating); PFAM: malic protein NAD-binding; malic protein domain protein; PRIAM: Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)); SPTR: Malate dehydrogenase (Oxaloacetate-decarboxylating).
   
 
 0.924
AFZ43718.1
NADPH-glutathione reductase; Maintains high levels of reduced glutathione.
 
 
 0.921
Your Current Organism:
Halothece sp. PCC7418
NCBI taxonomy Id: 65093
Other names: Aphanothece halophytica 7418, Cyanothece sp. PCC 7418, H. sp. PCC 7418, Halothece sp. PCC 7418, Synechococcus sp. ATCC 29534 (no longer available), Synechococcus sp. PCC 7418
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