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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AFZ45319.1MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase domain; TIGRFAM: MazG family protein; COGs: COG3956 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain; InterPro IPR011551:IPR004518; KEGG: cyc:PCC7424_0531 nucleoside triphosphate pyrophosphohydrolase; PFAM: MazG nucleotide pyrophosphohydrolase; SPTR: MazG family protein; TIGRFAM: MazG family protein. (273 aa)    
Predicted Functional Partners:
AFZ42375.1
Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
    
  0.903
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
    
  0.903
AFZ43810.1
PFAM: IMP dehydrogenase / GMP reductase domain; TIGRFAM: IMP dehydrogenase family protein; COGs: COG0516 IMP dehydrogenase/GMP reductase; InterPro IPR001093:IPR005992; KEGG: cyh:Cyan8802_0372 inosine 5-monophosphate dehydrogenase; PFAM: IMP dehydrogenase/GMP reductase; SPTR: Inositol-5-monophosphate dehydrogenase; TIGRFAM: IMP dehydrogenase family protein.
    
  0.903
AFZ42326.1
5'-Nucleotidase domain-containing protein; PFAM: CHRD domain; 5'-nucleotidase, C-terminal domain; COGs: COG0737 5'-nucleotidase/2' 3'-cyclic phosphodiesterase and related esterase; InterPro IPR006146:IPR010895:IPR008334:IPR001343; KEGG: amr:AM1_1876 5'-nucleotidase/2',3'-cyclic phosphodiesterase, putative; PFAM: 5'-Nucleotidase domain-containing protein; CHRD domain containing protein; Hemolysin-type calcium-binding region; SMART: CHRD domain containing protein; SPTR: 5'-nucleotidase/2',3'-cyclic phosphodiesterase, putative.
    
  0.900
AFZ42635.1
5'-nucleotidase; PFAM: Survival protein SurE; TIGRFAM: 5'/3'-nucleotidase SurE; COGs: COG0496 acid phosphatase; InterPro IPR002828; KEGG: cyh:Cyan8802_2176 stationary phase survival protein SurE; PFAM: Survival protein SurE; SPTR: Stationary-phase survival protein SurE; TIGRFAM: stationary-phase survival protein SurE; exopolyphosphatase.
     
 0.900
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
     
  0.900
surE
5'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
     
 0.900
AFZ45320.1
DoxX family protein; PFAM: DoxX; InterPro IPR011637:IPR002995; KEGG: ana:all3051 hypothetical protein; PFAM: DoxX family protein; Surfeit locus 4 family protein; SPTR: DoxX family protein.
       0.723
gpmI
Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate.
      0.602
glpK
Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family.
      0.557
Your Current Organism:
Halothece sp. PCC7418
NCBI taxonomy Id: 65093
Other names: Aphanothece halophytica 7418, Cyanothece sp. PCC 7418, H. sp. PCC 7418, Halothece sp. PCC 7418, Synechococcus sp. ATCC 29534 (no longer available), Synechococcus sp. PCC 7418
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