Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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from curated databases
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experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Score
CCK78394.1Putative thymidylate synthase. (266 aa)    
Predicted Functional Partners:
CCK82138.1
Fusion protein: glycine cleavage T-protein and glycine hydroxymethyltransferase.
 
 
 0.963
folD
FolD: bifunctional protein folD [includes: methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
  
 
 0.955
folA
FolA: dihydrofolate reductase; Signal peptide.
  
 
 0.953
CCK81529.1
CMP/dCMP deaminase zinc-binding.
  
 
 0.939
tmk
Tmk: thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
  
 
 0.936
glyA
GlyA: serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.926
CCK79070.1
Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.
 
  
 0.920
gcvPB
GcvPB: glycine dehydrogenase (decarboxylating), glycine cleavage system P protein, subunit 2.
    
 0.918
surE
SurE: 5?-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
   
 
 0.916
gcvPA
GcvPA: glycine dehydrogenase (decarboxylating), glycine cleavage system P protein, subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
    
 0.914
Your Current Organism:
Desulfobacula toluolica
NCBI taxonomy Id: 651182
Other names: D. toluolica Tol2, Desulfobacula toluolica DSM 7467, Desulfobacula toluolica Tol2, Desulfobacula toluolica str. Tol2, Desulfobacula toluolica strain Tol2
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