| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| hyfI | hypA | TOL2_C19530 | TOL2_C33800 | HyfI: predicted hydrogenase 4, component I (small subunit of [NiFe] hydrogenase). | HypA: hydrogenase nickel incorporation protein; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. | 0.577 |
| hyfI | hypC | TOL2_C19530 | TOL2_C07280 | HyfI: predicted hydrogenase 4, component I (small subunit of [NiFe] hydrogenase). | HypC: hydrogenase assembly chaperone. | 0.420 |
| hyfI | hypD | TOL2_C19530 | TOL2_C07300 | HyfI: predicted hydrogenase 4, component I (small subunit of [NiFe] hydrogenase). | HypD: hydrogenase formation protein; Belongs to the HypD family. | 0.404 |
| hyfI | hypE | TOL2_C19530 | TOL2_C07310 | HyfI: predicted hydrogenase 4, component I (small subunit of [NiFe] hydrogenase). | HypE: hydrogenase expression/formation protein. | 0.558 |
| hyfI | hypF | TOL2_C19530 | TOL2_C07290 | HyfI: predicted hydrogenase 4, component I (small subunit of [NiFe] hydrogenase). | HypF: hydrogenase maturation factor; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide. | 0.548 |
| hyfI | hysA | TOL2_C19530 | TOL2_C39200 | HyfI: predicted hydrogenase 4, component I (small subunit of [NiFe] hydrogenase). | HysA: periplasmic [NiFeSe] hydrogenase, small subunit. | 0.437 |
| hyfI | hysB | TOL2_C19530 | TOL2_C39190 | HyfI: predicted hydrogenase 4, component I (small subunit of [NiFe] hydrogenase). | HysB: periplasmic [NiFeSe] hydrogenase, large subunit; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. | 0.406 |
| hyfI | nifJ | TOL2_C19530 | TOL2_C40810 | HyfI: predicted hydrogenase 4, component I (small subunit of [NiFe] hydrogenase). | NifJ: pyruvate-flavodoxin oxidoreductase. | 0.979 |
| hypA | hyfI | TOL2_C33800 | TOL2_C19530 | HypA: hydrogenase nickel incorporation protein; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. | HyfI: predicted hydrogenase 4, component I (small subunit of [NiFe] hydrogenase). | 0.577 |
| hypA | hypB | TOL2_C33800 | TOL2_C33790 | HypA: hydrogenase nickel incorporation protein; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. | HypB: hydrogenase assesory protein. | 0.991 |
| hypA | hypC | TOL2_C33800 | TOL2_C07280 | HypA: hydrogenase nickel incorporation protein; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. | HypC: hydrogenase assembly chaperone. | 0.896 |
| hypA | hypD | TOL2_C33800 | TOL2_C07300 | HypA: hydrogenase nickel incorporation protein; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. | HypD: hydrogenase formation protein; Belongs to the HypD family. | 0.897 |
| hypA | hypE | TOL2_C33800 | TOL2_C07310 | HypA: hydrogenase nickel incorporation protein; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. | HypE: hydrogenase expression/formation protein. | 0.884 |
| hypA | hypF | TOL2_C33800 | TOL2_C07290 | HypA: hydrogenase nickel incorporation protein; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. | HypF: hydrogenase maturation factor; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide. | 0.873 |
| hypA | hysA | TOL2_C33800 | TOL2_C39200 | HypA: hydrogenase nickel incorporation protein; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. | HysA: periplasmic [NiFeSe] hydrogenase, small subunit. | 0.773 |
| hypA | hysB | TOL2_C33800 | TOL2_C39190 | HypA: hydrogenase nickel incorporation protein; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. | HysB: periplasmic [NiFeSe] hydrogenase, large subunit; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. | 0.948 |
| hypA | nifJ | TOL2_C33800 | TOL2_C40810 | HypA: hydrogenase nickel incorporation protein; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. | NifJ: pyruvate-flavodoxin oxidoreductase. | 0.571 |
| hypB | hypA | TOL2_C33790 | TOL2_C33800 | HypB: hydrogenase assesory protein. | HypA: hydrogenase nickel incorporation protein; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. | 0.991 |
| hypB | hypC | TOL2_C33790 | TOL2_C07280 | HypB: hydrogenase assesory protein. | HypC: hydrogenase assembly chaperone. | 0.967 |
| hypB | hypD | TOL2_C33790 | TOL2_C07300 | HypB: hydrogenase assesory protein. | HypD: hydrogenase formation protein; Belongs to the HypD family. | 0.972 |