CCK79004.1 protein (Desulfobacula toluolica)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

CCK79004.1

Conserved uncharacterized protein. (95 aa)

Predicted Functional Partners:

CCK79005.1

0.951

CCK80232.1

0.791

CCK79003.1

0.675

CCK79000.1

0.626

CCK81448.1

0.535

CCK78998.1

0.467

CCK79009.1

0.455

CCK79006.1

0.415

CCK78993.1

0.412

Your Current Organism:

Desulfobacula toluolica

NCBI taxonomy Id: 651182
Other names: D. toluolica Tol2, Desulfobacula toluolica DSM 7467, Desulfobacula toluolica Tol2, Desulfobacula toluolica str. Tol2, Desulfobacula toluolica strain Tol2

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCK78993.1	CCK79004.1	TOL2_C08250	TOL2_C08360	Conserved uncharacterized protein.	Conserved uncharacterized protein.	0.412
CCK78998.1	CCK79004.1	TOL2_C08300	TOL2_C08360	Conserved uncharacterized protein.	Conserved uncharacterized protein.	0.467
CCK79000.1	CCK79004.1	TOL2_C08320	TOL2_C08360	Conserved uncharacterized protein.	Conserved uncharacterized protein.	0.626
CCK79000.1	CCK79005.1	TOL2_C08320	TOL2_C08370	Conserved uncharacterized protein.	Conserved uncharacterized protein.	0.415
CCK79003.1	CCK79004.1	TOL2_C08350	TOL2_C08360	Putative lysozyme.	Conserved uncharacterized protein.	0.675
CCK79003.1	CCK79005.1	TOL2_C08350	TOL2_C08370	Putative lysozyme.	Conserved uncharacterized protein.	0.675
CCK79004.1	CCK78993.1	TOL2_C08360	TOL2_C08250	Conserved uncharacterized protein.	Conserved uncharacterized protein.	0.412
CCK79004.1	CCK78998.1	TOL2_C08360	TOL2_C08300	Conserved uncharacterized protein.	Conserved uncharacterized protein.	0.467
CCK79004.1	CCK79000.1	TOL2_C08360	TOL2_C08320	Conserved uncharacterized protein.	Conserved uncharacterized protein.	0.626
CCK79004.1	CCK79003.1	TOL2_C08360	TOL2_C08350	Conserved uncharacterized protein.	Putative lysozyme.	0.675
CCK79004.1	CCK79005.1	TOL2_C08360	TOL2_C08370	Conserved uncharacterized protein.	Conserved uncharacterized protein.	0.951
CCK79004.1	CCK79006.1	TOL2_C08360	TOL2_C08380	Conserved uncharacterized protein.	Uncharacterized protein.	0.415
CCK79004.1	CCK79009.1	TOL2_C08360	TOL2_C08410	Conserved uncharacterized protein.	Conserved uncharacterized protein.	0.455
CCK79004.1	CCK80232.1	TOL2_C08360	TOL2_C20710	Conserved uncharacterized protein.	Conserved uncharacterized protein.	0.791
CCK79004.1	CCK81448.1	TOL2_C08360	TOL2_C32910	Conserved uncharacterized protein.	HipA domain protein.	0.535
CCK79005.1	CCK79000.1	TOL2_C08370	TOL2_C08320	Conserved uncharacterized protein.	Conserved uncharacterized protein.	0.415
CCK79005.1	CCK79003.1	TOL2_C08370	TOL2_C08350	Conserved uncharacterized protein.	Putative lysozyme.	0.675
CCK79005.1	CCK79004.1	TOL2_C08370	TOL2_C08360	Conserved uncharacterized protein.	Conserved uncharacterized protein.	0.951
CCK79005.1	CCK79006.1	TOL2_C08370	TOL2_C08380	Conserved uncharacterized protein.	Uncharacterized protein.	0.400
CCK79006.1	CCK79004.1	TOL2_C08380	TOL2_C08360	Uncharacterized protein.	Conserved uncharacterized protein.	0.415

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

25

average node degree:

4.55

avg. local clustering coefficient:

0.909

expected number of edges:

15

PPI enrichment p-value:

0.0101

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000387

Spliceosomal snRNP assembly

4 of 18

2.3

2.42

2.16e-05

GO:0000398

mRNA splicing, via spliceosome

5 of 160

1.45

1.3

0.00062

GO:0090304

Nucleic acid metabolic process

9 of 1139

0.85

0.75

0.00030

GO:0016070

RNA metabolic process

7 of 860

0.86

0.66

0.0028

GO:0006259

DNA metabolic process

4 of 304

1.07

0.54

0.0485

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003676

Nucleic acid binding

10 of 1220

0.87

0.86

1.29e-05

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005682

U5 snRNP

4 of 12

2.48

3.09

1.26e-06

GO:0005685

U1 snRNP

4 of 14

2.41

3.06

1.26e-06

GO:0005687

U4 snRNP

3 of 5

2.73

2.82

6.03e-06

GO:0046540

U4/U6 x U5 tri-snRNP complex

4 of 23

2.19

2.76

3.03e-06

GO:0071004

U2-type prespliceosome

4 of 25

2.16

2.74

3.03e-06

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5306

U4 snRNP, and U1 snRNP

4 of 6

2.78

3.51

3.09e-07

CL:5898

Mixed, incl. Replication fork, and HDR through Single Strand Annealing (SSA)

4 of 56

1.81

1.82

0.00012

CL:5958

DNA polymerase complex

2 of 12

2.17

1.13

0.0075

CL:5900

Mixed, incl. HDR through Single Strand Annealing (SSA), and Mitotic recombination

2 of 24

1.87

0.84

0.0246

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03440

Homologous recombination

3 of 44

1.79

1.28

0.0024

map03040

Spliceosome

4 of 149

1.38

1.08

0.0024

map03410

Base excision repair

2 of 36

1.7

0.72

0.0390

map03430

Mismatch repair

2 of 40

1.65

0.71

0.0390

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-72163

mRNA Splicing - Major Pathway

4 of 110

1.51

1.05

0.0049

MAP-72172

mRNA Splicing

4 of 119

1.48

1.03

0.0049

MAP-77588

SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

2 of 7

2.41

1.03

0.0127

MAP-111367

SLBP independent Processing of Histone Pre-mRNAs

2 of 7

2.41

1.03

0.0127

MAP-72203

Processing of Capped Intron-Containing Pre-mRNA

4 of 198

1.26

0.79

0.0127

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0034719

SMN-Sm protein complex

2 of 4

2.65

1.13

0.0089

GOCC:0005687

U4 snRNP

2 of 4

2.65

1.13

0.0089

GOCC:0043625

Delta DNA polymerase complex

2 of 6

2.48

1.12

0.0089

GOCC:0120114

Sm-like protein family complex

3 of 36

1.87

1.05

0.0089

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0508

mRNA splicing

4 of 13

2.44

3.29

4.68e-07

KW-0687

Ribonucleoprotein

4 of 85

1.63

1.68

0.00012

KW-0747

Spliceosome

2 of 6

2.48

1.53

0.0015

KW-0539

Nucleus

7 of 388

1.21

1.45

3.53e-06

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR047575

Sm domain

4 of 16

2.35

2.57

1.14e-05

IPR001163

Sm domain, eukaryotic/archaea-type

4 of 16

2.35

2.57

1.14e-05

IPR010920

LSM domain superfamily

4 of 19

2.28

2.54

1.14e-05

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00651

snRNP Sm proteins

4 of 16

2.35

3.03

1.29e-06

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