| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCK79252.1 | lysC | TOL2_C10870 | TOL2_C10860 | Conserved uncharacterized protein, UPF0079. | LysC: aspartokinase (aspartate kinase); Belongs to the aspartokinase family. | 0.899 |
| CCK79252.1 | nnrD | TOL2_C10870 | TOL2_C10880 | Conserved uncharacterized protein, UPF0079. | YjeF: uncharacterized predicted carbohydrate kinase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase [...] | 0.945 |
| CCK79252.1 | tag | TOL2_C10870 | TOL2_C10890 | Conserved uncharacterized protein, UPF0079. | Tag: DNA-3-methyladenine glycosylase I. | 0.534 |
| CCK79255.1 | CCK79256.1 | TOL2_C10910 | TOL2_C10920 | Two component system sensor histidine kinase, hybrid. | Two component transcriptional regulator, sigma54-specific. | 0.860 |
| CCK79255.1 | tag | TOL2_C10910 | TOL2_C10890 | Two component system sensor histidine kinase, hybrid. | Tag: DNA-3-methyladenine glycosylase I. | 0.422 |
| CCK79256.1 | CCK79255.1 | TOL2_C10920 | TOL2_C10910 | Two component transcriptional regulator, sigma54-specific. | Two component system sensor histidine kinase, hybrid. | 0.860 |
| CCK79256.1 | tag | TOL2_C10920 | TOL2_C10890 | Two component transcriptional regulator, sigma54-specific. | Tag: DNA-3-methyladenine glycosylase I. | 0.422 |
| guaA | lysC | TOL2_C14360 | TOL2_C10860 | GuaA: GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | LysC: aspartokinase (aspartate kinase); Belongs to the aspartokinase family. | 0.489 |
| guaA | polA | TOL2_C14360 | TOL2_C38880 | GuaA: GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | PolA: DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.780 |
| guaA | tag | TOL2_C14360 | TOL2_C10890 | GuaA: GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Tag: DNA-3-methyladenine glycosylase I. | 0.896 |
| lysC | CCK79252.1 | TOL2_C10860 | TOL2_C10870 | LysC: aspartokinase (aspartate kinase); Belongs to the aspartokinase family. | Conserved uncharacterized protein, UPF0079. | 0.899 |
| lysC | guaA | TOL2_C10860 | TOL2_C14360 | LysC: aspartokinase (aspartate kinase); Belongs to the aspartokinase family. | GuaA: GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.489 |
| lysC | nnrD | TOL2_C10860 | TOL2_C10880 | LysC: aspartokinase (aspartate kinase); Belongs to the aspartokinase family. | YjeF: uncharacterized predicted carbohydrate kinase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase [...] | 0.778 |
| lysC | tag | TOL2_C10860 | TOL2_C10890 | LysC: aspartokinase (aspartate kinase); Belongs to the aspartokinase family. | Tag: DNA-3-methyladenine glycosylase I. | 0.539 |
| nnrD | CCK79252.1 | TOL2_C10880 | TOL2_C10870 | YjeF: uncharacterized predicted carbohydrate kinase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase [...] | Conserved uncharacterized protein, UPF0079. | 0.945 |
| nnrD | lysC | TOL2_C10880 | TOL2_C10860 | YjeF: uncharacterized predicted carbohydrate kinase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase [...] | LysC: aspartokinase (aspartate kinase); Belongs to the aspartokinase family. | 0.778 |
| nnrD | tag | TOL2_C10880 | TOL2_C10890 | YjeF: uncharacterized predicted carbohydrate kinase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase [...] | Tag: DNA-3-methyladenine glycosylase I. | 0.590 |
| ogt | polA | TOL2_C01030 | TOL2_C38880 | Ogt: methylated-DNA--protein-cysteine methyltransferase (6-o-methylguanine-dna methyltransferase); Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. | PolA: DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.574 |
| ogt | tag | TOL2_C01030 | TOL2_C10890 | Ogt: methylated-DNA--protein-cysteine methyltransferase (6-o-methylguanine-dna methyltransferase); Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. | Tag: DNA-3-methyladenine glycosylase I. | 0.701 |
| polA | guaA | TOL2_C38880 | TOL2_C14360 | PolA: DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | GuaA: GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.780 |