| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCK78761.1 | CCK82138.1 | TOL2_C05930 | TOL2_C39830 | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Fusion protein: glycine cleavage T-protein and glycine hydroxymethyltransferase. | 0.581 |
| CCK78761.1 | fchA | TOL2_C05930 | TOL2_C11860 | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | FchA: methenyltetrahydrofolate cyclohydrolase. | 0.907 |
| CCK78761.1 | fhs | TOL2_C05930 | TOL2_C11840 | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Fhs: formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.475 |
| CCK78761.1 | folD | TOL2_C05930 | TOL2_C11850 | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | FolD: bifunctional protein folD [includes: methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.927 |
| CCK78761.1 | ftcD | TOL2_C05930 | TOL2_C11400 | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | FtcD: formimidoyltetrahydrofolate cyclodeaminase. | 0.907 |
| CCK80999.1 | CCK82138.1 | TOL2_C28390 | TOL2_C39830 | Predicted dihydropteroate synthase. | Fusion protein: glycine cleavage T-protein and glycine hydroxymethyltransferase. | 0.922 |
| CCK80999.1 | fhs | TOL2_C28390 | TOL2_C11840 | Predicted dihydropteroate synthase. | Fhs: formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.915 |
| CCK80999.1 | ftcD | TOL2_C28390 | TOL2_C11400 | Predicted dihydropteroate synthase. | FtcD: formimidoyltetrahydrofolate cyclodeaminase. | 0.909 |
| CCK80999.1 | glyA | TOL2_C28390 | TOL2_C33730 | Predicted dihydropteroate synthase. | GlyA: serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.908 |
| CCK80999.1 | purH1 | TOL2_C28390 | TOL2_C10120 | Predicted dihydropteroate synthase. | PurH1: phosphoribosylaminoimidazolecarboxamide formyltransferase. | 0.900 |
| CCK82138.1 | CCK78761.1 | TOL2_C39830 | TOL2_C05930 | Fusion protein: glycine cleavage T-protein and glycine hydroxymethyltransferase. | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | 0.581 |
| CCK82138.1 | CCK80999.1 | TOL2_C39830 | TOL2_C28390 | Fusion protein: glycine cleavage T-protein and glycine hydroxymethyltransferase. | Predicted dihydropteroate synthase. | 0.922 |
| CCK82138.1 | fchA | TOL2_C39830 | TOL2_C11860 | Fusion protein: glycine cleavage T-protein and glycine hydroxymethyltransferase. | FchA: methenyltetrahydrofolate cyclohydrolase. | 0.956 |
| CCK82138.1 | fhs | TOL2_C39830 | TOL2_C11840 | Fusion protein: glycine cleavage T-protein and glycine hydroxymethyltransferase. | Fhs: formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.994 |
| CCK82138.1 | folD | TOL2_C39830 | TOL2_C11850 | Fusion protein: glycine cleavage T-protein and glycine hydroxymethyltransferase. | FolD: bifunctional protein folD [includes: methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.995 |
| CCK82138.1 | ftcD | TOL2_C39830 | TOL2_C11400 | Fusion protein: glycine cleavage T-protein and glycine hydroxymethyltransferase. | FtcD: formimidoyltetrahydrofolate cyclodeaminase. | 0.946 |
| CCK82138.1 | glyA | TOL2_C39830 | TOL2_C33730 | Fusion protein: glycine cleavage T-protein and glycine hydroxymethyltransferase. | GlyA: serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.973 |
| CCK82138.1 | purH1 | TOL2_C39830 | TOL2_C10120 | Fusion protein: glycine cleavage T-protein and glycine hydroxymethyltransferase. | PurH1: phosphoribosylaminoimidazolecarboxamide formyltransferase. | 0.991 |
| CCK82138.1 | speB | TOL2_C39830 | TOL2_C01070 | Fusion protein: glycine cleavage T-protein and glycine hydroxymethyltransferase. | SpeB: agmatinase (Agmatine ureohydrolase); Belongs to the arginase family. | 0.566 |
| fchA | CCK78761.1 | TOL2_C11860 | TOL2_C05930 | FchA: methenyltetrahydrofolate cyclohydrolase. | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | 0.907 |