Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Score
fhsFhs: formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. (591 aa)    
Predicted Functional Partners:
folD
FolD: bifunctional protein folD [includes: methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
 
 0.998
CCK82138.1
Fusion protein: glycine cleavage T-protein and glycine hydroxymethyltransferase.
  
 0.994
purH2
PurH2: phosphoribosylaminoimidazolecarboxamide formyltransferase.
 
 0.977
glyA
GlyA: serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 0.974
purH1
PurH1: phosphoribosylaminoimidazolecarboxamide formyltransferase.
  
 0.973
purN
PurN: phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
  
 0.972
purD
PurD: phosphoribosylamine--glycine ligase (glycinamide ribonucleotide synthetase); Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR); Belongs to the GARS family.
  
 
 0.962
cdhC
CdhC: CO dehydrogenase/acetyl-CoA synthase complex, beta subunit.
    
 0.957
ftcD
FtcD: formimidoyltetrahydrofolate cyclodeaminase.
 
  
 0.945
fchA
FchA: methenyltetrahydrofolate cyclohydrolase.
    
 0.934
Your Current Organism:
Desulfobacula toluolica
NCBI taxonomy Id: 651182
Other names: D. toluolica Tol2, Desulfobacula toluolica DSM 7467, Desulfobacula toluolica Tol2, Desulfobacula toluolica str. Tol2, Desulfobacula toluolica strain Tol2
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