| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCK81789.1 | cyaA2 | TOL2_C36320 | TOL2_C14490 | Predicted polyketide synthase. | Cya: adenylate cyclase. | 0.706 |
| CCK81789.1 | gyrB | TOL2_C36320 | TOL2_C00020 | Predicted polyketide synthase. | GyrB: DNA gyrase, subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.529 |
| CCK81789.1 | ispH | TOL2_C36320 | TOL2_C36360 | Predicted polyketide synthase. | IspH: predicted 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. | 0.681 |
| CCK81789.1 | metS | TOL2_C36320 | TOL2_C13250 | Predicted polyketide synthase. | MetG: methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.560 |
| CCK81789.1 | parC | TOL2_C36320 | TOL2_C14470 | Predicted polyketide synthase. | ParC: DNA topoisomerase 4, subunit A; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily. | 0.678 |
| CCK81789.1 | parE | TOL2_C36320 | TOL2_C14480 | Predicted polyketide synthase. | ParE: DNA topoisomerase 4, subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily. | 0.529 |
| CCK81789.1 | topA | TOL2_C36320 | TOL2_C14380 | Predicted polyketide synthase. | TopA: DNA topoisomerase 1; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DN [...] | 0.594 |
| CCK82539.1 | CCK82540.1 | TOL2_C43810 | TOL2_C43820 | Conserved uncharacterized protein. | Conserved uncharacterized protein. | 0.986 |
| CCK82539.1 | parC | TOL2_C43810 | TOL2_C14470 | Conserved uncharacterized protein. | ParC: DNA topoisomerase 4, subunit A; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily. | 0.734 |
| CCK82540.1 | CCK82539.1 | TOL2_C43820 | TOL2_C43810 | Conserved uncharacterized protein. | Conserved uncharacterized protein. | 0.986 |
| CCK82540.1 | parC | TOL2_C43820 | TOL2_C14470 | Conserved uncharacterized protein. | ParC: DNA topoisomerase 4, subunit A; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily. | 0.734 |
| cyaA2 | CCK81789.1 | TOL2_C14490 | TOL2_C36320 | Cya: adenylate cyclase. | Predicted polyketide synthase. | 0.706 |
| cyaA2 | mltF | TOL2_C14490 | TOL2_C14460 | Cya: adenylate cyclase. | MltF: membrane-bound lytic murein transglycosylase F; Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella. In the N-terminal section; belongs to the bacterial solute- binding protein 3 family. | 0.654 |
| cyaA2 | parC | TOL2_C14490 | TOL2_C14470 | Cya: adenylate cyclase. | ParC: DNA topoisomerase 4, subunit A; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily. | 0.660 |
| cyaA2 | parE | TOL2_C14490 | TOL2_C14480 | Cya: adenylate cyclase. | ParE: DNA topoisomerase 4, subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily. | 0.604 |
| gyrB | CCK81789.1 | TOL2_C00020 | TOL2_C36320 | GyrB: DNA gyrase, subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | Predicted polyketide synthase. | 0.529 |
| gyrB | metS | TOL2_C00020 | TOL2_C13250 | GyrB: DNA gyrase, subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | MetG: methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.564 |
| gyrB | parC | TOL2_C00020 | TOL2_C14470 | GyrB: DNA gyrase, subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | ParC: DNA topoisomerase 4, subunit A; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily. | 0.996 |
| gyrB | topA | TOL2_C00020 | TOL2_C14380 | GyrB: DNA gyrase, subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | TopA: DNA topoisomerase 1; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DN [...] | 0.568 |
| ispH | CCK81789.1 | TOL2_C36360 | TOL2_C36320 | IspH: predicted 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. | Predicted polyketide synthase. | 0.681 |
