Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ilvHIlvH: acetolyctate synthase, small subunit 2.2.1.6. (163 aa)    
Predicted Functional Partners:
ilvG
IlgV: acetolactate synthase, large subunit.
 0.999
ilvC
IlvC: ketol-acid reductoisomerase (Acetohydroxy-acid isomeroreductase); Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
 0.996
leuB
LeuB: 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
 
 0.994
ilvD
IlvD: dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family.
 
 
 0.991
leuA3
LeuA3, 2-isopropylmalate synthase 2.3.3.13; Belongs to the alpha-IPM synthase/homocitrate synthase family.
 
 
 0.979
leuA2
LeuA2: 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
 
 
 0.976
nifJ
NifJ: pyruvate-flavodoxin oxidoreductase.
  
 
 0.936
korA3
KorA3: 2-oxoglutarate synthase, alpha subunit.
  
 
 0.922
korA
KorA: 2-oxoglutarate synthase, alpha subunit (2-ketoglutarate oxidoreductase alpha chain).
  
 
 0.915
korA2
KorA2: 2-oxoglutarate synthase, subunit A.
  
 
 0.915
Your Current Organism:
Desulfobacula toluolica
NCBI taxonomy Id: 651182
Other names: D. toluolica Tol2, Desulfobacula toluolica DSM 7467, Desulfobacula toluolica Tol2, Desulfobacula toluolica str. Tol2, Desulfobacula toluolica strain Tol2
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