Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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lipALipA: lipoyl synthase (lipoate synthase); Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (288 aa)    
Predicted Functional Partners:
lipB
LipB: lipoyl(octanoyl) transferas (lipoate-protein ligase B); Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
 
 0.999
gcvH
GcvH: glycine cleavage system, H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
 
 0.928
gcvPB
GcvPB: glycine dehydrogenase (decarboxylating), glycine cleavage system P protein, subunit 2.
 
  
 0.808
gcvPA
GcvPA: glycine dehydrogenase (decarboxylating), glycine cleavage system P protein, subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
 
   
 0.781
CCK79482.1
Glycine cleavage H-protein.
 
 0.734
CCK79483.1
Glycine cleavage H-protein.
 
 0.728
lpdA
LpdA: dihydrolipoyl dehydrogenase (E3 component of 2-oxoglutarate dehydrogenase complex).
  
 0.717
CCK79853.1
Putative glycine cleavage system H protein.
  
 0.685
CCK82138.1
Fusion protein: glycine cleavage T-protein and glycine hydroxymethyltransferase.
 
  
 0.643
pfaA
PfaA: polyketide-type polyunsaturated fatty acid synthase.
  
 
 0.554
Your Current Organism:
Desulfobacula toluolica
NCBI taxonomy Id: 651182
Other names: D. toluolica Tol2, Desulfobacula toluolica DSM 7467, Desulfobacula toluolica Tol2, Desulfobacula toluolica str. Tol2, Desulfobacula toluolica strain Tol2
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