Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
mnmAMnmA: tRNA-specific 2-thiouridylase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. (355 aa)    
Predicted Functional Partners:
miaB-2
MiaB: (dimethylallyl)adenosine tRNA emthylthiotransferase.
  
  
 0.860
CCK80272.1
Predicted 4Fe-4S ferredoxin.
       0.826
gidA
GidA: tRNA uridine 5-carboxymethylaminomethyl modification enzyme; NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34; Belongs to the MnmG family.
  
 0.781
mnmE
MnmE: tRNA modification GTPase; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
 
 0.773
purB
PurB: adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
 
  
 0.767
ribF
RibF: riboflavin biosynthesis protein [Includes: riboflavin kinase (flavokinase); FMN adenylyltransferase (FAD pyrophosphorylase)]; Belongs to the ribF family.
 
  
 0.702
CCK79790.1
Conserved uncharacterized protein.
    
 0.674
iscS
IscS: cysteine desulfurase; Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine.
 
  
 0.641
metS
MetG: methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
  
  
 0.630
trmD
TrmD: tRNA (guanine-N(1)-)-methyltransferase; Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family.
 
  
 0.626
Your Current Organism:
Desulfobacula toluolica
NCBI taxonomy Id: 651182
Other names: D. toluolica Tol2, Desulfobacula toluolica DSM 7467, Desulfobacula toluolica Tol2, Desulfobacula toluolica str. Tol2, Desulfobacula toluolica strain Tol2
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