STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pyrCPyrC: dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (437 aa)    
Predicted Functional Partners:
pyrB
PyrB: aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
 0.999
pyrD
PyrD: dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate.
 
 0.992
carA
CarA: carbamoyl-phosphate synthase, small chain; Belongs to the CarA family.
  
 0.991
carB2
CarB2: carbamoyl-phosphate synthase, large chain; Belongs to the CarB family.
 
 0.978
pyrR
PyrR: bifunctional protein pyrR (pyrimidine operon regulatory protein; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
 
 
 0.976
carB
CarB: carbamoyl-phosphate synthase, large chain; Belongs to the CarB family.
 
 0.976
pyrK
PyrK: dihydroorotate dehydrogenase electron transfer subunit.
  
 
 0.962
argF
ArgF: ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
  
 0.933
pyrF
PyrF: orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.
 
  
 0.886
CCK80354.1
Predicted signal peptidase I; Belongs to the peptidase S26 family.
       0.828
Your Current Organism:
Desulfobacula toluolica
NCBI taxonomy Id: 651182
Other names: D. toluolica Tol2, Desulfobacula toluolica DSM 7467, Desulfobacula toluolica Tol2, Desulfobacula toluolica str. Tol2, Desulfobacula toluolica strain Tol2
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