CCK80436.1 protein (Desulfobacula toluolica)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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[Homology]

Score

CCK80436.1

Type II and III secretion system protein; Signal peptide; Belongs to the bacterial secretin family. (459 aa)

Predicted Functional Partners:

cpaB

0.988

CCK80431.1

0.964

CCK80430.1

0.954

CCK80429.1

0.946

CCK80428.1

0.940

CCK80434.1

0.932

cpaA

0.920

CCK81598.1

0.920

CCK80433.1

0.913

CCK80432.1

0.863

Your Current Organism:

Desulfobacula toluolica

NCBI taxonomy Id: 651182
Other names: D. toluolica Tol2, Desulfobacula toluolica DSM 7467, Desulfobacula toluolica Tol2, Desulfobacula toluolica str. Tol2, Desulfobacula toluolica strain Tol2

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCK80428.1	CCK80429.1	TOL2_C22670	TOL2_C22680	Predicted type II secretion system protein; Signal peptide.	Type II secretion system protein.	0.993
CCK80428.1	CCK80430.1	TOL2_C22670	TOL2_C22690	Predicted type II secretion system protein; Signal peptide.	Type II secretion system protein E.	0.971
CCK80428.1	CCK80431.1	TOL2_C22670	TOL2_C22700	Predicted type II secretion system protein; Signal peptide.	Putative response regulator protein.	0.975
CCK80428.1	CCK80432.1	TOL2_C22670	TOL2_C22710	Predicted type II secretion system protein; Signal peptide.	Uncharacterized protein.	0.800
CCK80428.1	CCK80433.1	TOL2_C22670	TOL2_C22720	Predicted type II secretion system protein; Signal peptide.	TadE family protein; Signal anchor.	0.943
CCK80428.1	CCK80434.1	TOL2_C22670	TOL2_C22730	Predicted type II secretion system protein; Signal peptide.	Putative TadE family protein; Signal peptide.	0.935
CCK80428.1	CCK80436.1	TOL2_C22670	TOL2_C22750	Predicted type II secretion system protein; Signal peptide.	Type II and III secretion system protein; Signal peptide; Belongs to the bacterial secretin family.	0.940
CCK80428.1	CCK81598.1	TOL2_C22670	TOL2_C34410	Predicted type II secretion system protein; Signal peptide.	Type II secretion system protein E.	0.921
CCK80428.1	cpaA	TOL2_C22670	TOL2_C22770	Predicted type II secretion system protein; Signal peptide.	CpaA: Flp pilus assembly protein, protease; Signal anchor.	0.881
CCK80428.1	cpaB	TOL2_C22670	TOL2_C22760	Predicted type II secretion system protein; Signal peptide.	CpaB: Flp pilus assembly protein; Signal peptide.	0.973
CCK80429.1	CCK80428.1	TOL2_C22680	TOL2_C22670	Type II secretion system protein.	Predicted type II secretion system protein; Signal peptide.	0.993
CCK80429.1	CCK80430.1	TOL2_C22680	TOL2_C22690	Type II secretion system protein.	Type II secretion system protein E.	0.981
CCK80429.1	CCK80431.1	TOL2_C22680	TOL2_C22700	Type II secretion system protein.	Putative response regulator protein.	0.990
CCK80429.1	CCK80432.1	TOL2_C22680	TOL2_C22710	Type II secretion system protein.	Uncharacterized protein.	0.859
CCK80429.1	CCK80433.1	TOL2_C22680	TOL2_C22720	Type II secretion system protein.	TadE family protein; Signal anchor.	0.962
CCK80429.1	CCK80434.1	TOL2_C22680	TOL2_C22730	Type II secretion system protein.	Putative TadE family protein; Signal peptide.	0.956
CCK80429.1	CCK80436.1	TOL2_C22680	TOL2_C22750	Type II secretion system protein.	Type II and III secretion system protein; Signal peptide; Belongs to the bacterial secretin family.	0.946
CCK80429.1	CCK81598.1	TOL2_C22680	TOL2_C34410	Type II secretion system protein.	Type II secretion system protein E.	0.932
CCK80429.1	cpaA	TOL2_C22680	TOL2_C22770	Type II secretion system protein.	CpaA: Flp pilus assembly protein, protease; Signal anchor.	0.880
CCK80429.1	cpaB	TOL2_C22680	TOL2_C22760	Type II secretion system protein.	CpaB: Flp pilus assembly protein; Signal peptide.	0.979

page 1 of 6

Network Stats

number of nodes:

2

number of edges:

1

average node degree:

1

avg. local clustering coefficient:

1

expected number of edges:

1

PPI enrichment p-value:

0.5

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004040

Amidase activity

4 of 4

2.12

2.15

5.57e-05

GO:0016811

Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

5 of 18

1.56

1.7

6.18e-05

GO:0016787

Hydrolase activity

9 of 260

0.66

0.53

0.0010

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005576

Extracellular region

3 of 19

1.32

0.63

0.0421

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:895

Carboxypeptidase activity, and N-acetylmuramoyl-L-alanine amidase activity

3 of 6

1.82

1.04

0.0087

CL:830

Cell division, and Regulation of cell shape

4 of 39

1.13

0.61

0.0311

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map01503

Cationic antimicrobial peptide (CAMP) resistance

7 of 20

1.66

2.84

9.95e-09

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005576

Extracellular region

6 of 44

1.25

1.29

9.41e-05

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00287

Bacterial SH3 domain homologues

2 of 4

1.82

0.71

0.0448

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