| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCK78394.1 | CCK82138.1 | TOL2_C02240 | TOL2_C39830 | Putative thymidylate synthase. | Fusion protein: glycine cleavage T-protein and glycine hydroxymethyltransferase. | 0.963 |
| CCK78394.1 | folD | TOL2_C02240 | TOL2_C11850 | Putative thymidylate synthase. | FolD: bifunctional protein folD [includes: methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.955 |
| CCK78394.1 | glyA | TOL2_C02240 | TOL2_C33730 | Putative thymidylate synthase. | GlyA: serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.926 |
| CCK78394.1 | metF4 | TOL2_C02240 | TOL2_C25700 | Putative thymidylate synthase. | MetF4: 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.907 |
| CCK78699.1 | cdhD | TOL2_C05310 | TOL2_C11830 | Dihydropteroate synthase (DHPS). | CdhD: CO dehydrogenase/acetyl-CoA synthase complex, delta subunit. | 0.967 |
| CCK78699.1 | metF4 | TOL2_C05310 | TOL2_C25700 | Dihydropteroate synthase (DHPS). | MetF4: 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.959 |
| CCK78699.1 | metH | TOL2_C05310 | TOL2_C11790 | Dihydropteroate synthase (DHPS). | MetH: 5-methyltetrahydrofolate corrinoid/iron-sulfur protein methyltransferase. | 0.923 |
| CCK80730.1 | cdhD | TOL2_C25710 | TOL2_C11830 | Uncharacterized protein. | CdhD: CO dehydrogenase/acetyl-CoA synthase complex, delta subunit. | 0.666 |
| CCK80730.1 | metF4 | TOL2_C25710 | TOL2_C25700 | Uncharacterized protein. | MetF4: 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.945 |
| CCK80730.1 | metH | TOL2_C25710 | TOL2_C11790 | Uncharacterized protein. | MetH: 5-methyltetrahydrofolate corrinoid/iron-sulfur protein methyltransferase. | 0.404 |
| CCK80999.1 | CCK82138.1 | TOL2_C28390 | TOL2_C39830 | Predicted dihydropteroate synthase. | Fusion protein: glycine cleavage T-protein and glycine hydroxymethyltransferase. | 0.922 |
| CCK80999.1 | cdhD | TOL2_C28390 | TOL2_C11830 | Predicted dihydropteroate synthase. | CdhD: CO dehydrogenase/acetyl-CoA synthase complex, delta subunit. | 0.687 |
| CCK80999.1 | glyA | TOL2_C28390 | TOL2_C33730 | Predicted dihydropteroate synthase. | GlyA: serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.908 |
| CCK80999.1 | metF4 | TOL2_C28390 | TOL2_C25700 | Predicted dihydropteroate synthase. | MetF4: 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.956 |
| CCK82138.1 | CCK78394.1 | TOL2_C39830 | TOL2_C02240 | Fusion protein: glycine cleavage T-protein and glycine hydroxymethyltransferase. | Putative thymidylate synthase. | 0.963 |
| CCK82138.1 | CCK80999.1 | TOL2_C39830 | TOL2_C28390 | Fusion protein: glycine cleavage T-protein and glycine hydroxymethyltransferase. | Predicted dihydropteroate synthase. | 0.922 |
| CCK82138.1 | folD | TOL2_C39830 | TOL2_C11850 | Fusion protein: glycine cleavage T-protein and glycine hydroxymethyltransferase. | FolD: bifunctional protein folD [includes: methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.995 |
| CCK82138.1 | glyA | TOL2_C39830 | TOL2_C33730 | Fusion protein: glycine cleavage T-protein and glycine hydroxymethyltransferase. | GlyA: serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.973 |
| CCK82138.1 | metF4 | TOL2_C39830 | TOL2_C25700 | Fusion protein: glycine cleavage T-protein and glycine hydroxymethyltransferase. | MetF4: 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.945 |
| CCK82373.1 | cdhD | TOL2_C42170 | TOL2_C11830 | Conserved uncharacterized protein. | CdhD: CO dehydrogenase/acetyl-CoA synthase complex, delta subunit. | 0.697 |
