CCK80803.1 protein (Desulfobacula toluolica)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

CCK80803.1

Putative two component system sensor histidine kinase. (386 aa)

Predicted Functional Partners:

lytT

0.979

CCK81956.1

0.977

CCK81418.1

0.968

CCK79237.1

0.966

CCK78832.1

0.954

CCK79301.1

0.950

CCK79830.1

0.948

CCK80058.1

0.944

CCK81079.1

0.941

CCK79042.1

0.932

Your Current Organism:

Desulfobacula toluolica

NCBI taxonomy Id: 651182
Other names: D. toluolica Tol2, Desulfobacula toluolica DSM 7467, Desulfobacula toluolica Tol2, Desulfobacula toluolica str. Tol2, Desulfobacula toluolica strain Tol2

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCK78832.1	CCK79042.1	TOL2_C06630	TOL2_C08740	Two component system sensor kinase, hybrid.	Two component system sensor histidine kinase, barA-like.	0.981
CCK78832.1	CCK79237.1	TOL2_C06630	TOL2_C10720	Two component system sensor kinase, hybrid.	Two component system response regulator, sigma54-specific; Signal peptide.	0.614
CCK78832.1	CCK79301.1	TOL2_C06630	TOL2_C11370	Two component system sensor kinase, hybrid.	Two component system sensor histidine kinase.	0.951
CCK78832.1	CCK79830.1	TOL2_C06630	TOL2_C16680	Two component system sensor kinase, hybrid.	Two component system sensor histidine kinase, hybrid.	0.975
CCK78832.1	CCK80058.1	TOL2_C06630	TOL2_C18970	Two component system sensor kinase, hybrid.	Two component system sensor histidine kinase.	0.987
CCK78832.1	CCK80803.1	TOL2_C06630	TOL2_C26440	Two component system sensor kinase, hybrid.	Putative two component system sensor histidine kinase.	0.954
CCK78832.1	CCK81079.1	TOL2_C06630	TOL2_C29190	Two component system sensor kinase, hybrid.	Two component system sensor histidine kinase, hybrid.	0.976
CCK78832.1	CCK81418.1	TOL2_C06630	TOL2_C32610	Two component system sensor kinase, hybrid.	Two component system sensor histidine kinase, hybrid; Signal peptide.	0.976
CCK78832.1	CCK81956.1	TOL2_C06630	TOL2_C38000	Two component system sensor kinase, hybrid.	Two component system sensor histidine kinase.	0.751
CCK79042.1	CCK78832.1	TOL2_C08740	TOL2_C06630	Two component system sensor histidine kinase, barA-like.	Two component system sensor kinase, hybrid.	0.981
CCK79042.1	CCK79237.1	TOL2_C08740	TOL2_C10720	Two component system sensor histidine kinase, barA-like.	Two component system response regulator, sigma54-specific; Signal peptide.	0.593
CCK79042.1	CCK79301.1	TOL2_C08740	TOL2_C11370	Two component system sensor histidine kinase, barA-like.	Two component system sensor histidine kinase.	0.846
CCK79042.1	CCK79830.1	TOL2_C08740	TOL2_C16680	Two component system sensor histidine kinase, barA-like.	Two component system sensor histidine kinase, hybrid.	0.976
CCK79042.1	CCK80058.1	TOL2_C08740	TOL2_C18970	Two component system sensor histidine kinase, barA-like.	Two component system sensor histidine kinase.	0.983
CCK79042.1	CCK80803.1	TOL2_C08740	TOL2_C26440	Two component system sensor histidine kinase, barA-like.	Putative two component system sensor histidine kinase.	0.932
CCK79042.1	CCK81079.1	TOL2_C08740	TOL2_C29190	Two component system sensor histidine kinase, barA-like.	Two component system sensor histidine kinase, hybrid.	0.973
CCK79042.1	CCK81418.1	TOL2_C08740	TOL2_C32610	Two component system sensor histidine kinase, barA-like.	Two component system sensor histidine kinase, hybrid; Signal peptide.	0.972
CCK79042.1	CCK81956.1	TOL2_C08740	TOL2_C38000	Two component system sensor histidine kinase, barA-like.	Two component system sensor histidine kinase.	0.874
CCK79237.1	CCK78832.1	TOL2_C10720	TOL2_C06630	Two component system response regulator, sigma54-specific; Signal peptide.	Two component system sensor kinase, hybrid.	0.614
CCK79237.1	CCK79042.1	TOL2_C10720	TOL2_C08740	Two component system response regulator, sigma54-specific; Signal peptide.	Two component system sensor histidine kinase, barA-like.	0.593

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

22

average node degree:

4

avg. local clustering coefficient:

0.876

expected number of edges:

10

PPI enrichment p-value:

0.00102

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006284

Base-excision repair

7 of 20

2.44

5.78

1.47e-12

GO:0006285

Base-excision repair, AP site formation

5 of 8

2.69

4.53

2.62e-09

GO:0006281

DNA repair

8 of 234

1.43

2.13

6.25e-08

GO:0097510

Base-excision repair, AP site formation via deaminated base removal

2 of 2

2.89

1.41

0.0028

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019104

DNA N-glycosylase activity

5 of 12

2.51

4.26

5.27e-09

GO:0003906

DNA-(apurinic or apyrimidinic site) endonuclease activity

4 of 5

2.79

3.91

5.28e-08

GO:0140097

Catalytic activity, acting on DNA

9 of 153

1.66

3.39

1.87e-11

GO:0000702

Oxidized base lesion DNA N-glycosylase activity

3 of 8

2.47

2.28

5.29e-05

GO:0140078

Class I DNA-(apurinic or apyrimidinic site) endonuclease activity

2 of 3

2.72

1.47

0.0021

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7191

Base-excision repair

5 of 10

2.59

4.32

5.37e-09

CL:7196

DNA-(apurinic or apyrimidinic site) endonuclease activity, and DNA dealkylation

4 of 5

2.79

3.7

1.38e-07

CL:6867

DNA metabolic process

7 of 175

1.49

2.17

2.66e-07

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03410

Base excision repair

7 of 40

2.13

4.97

4.54e-12

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-73929

Base-Excision Repair, AP Site Formation

4 of 14

2.35

2.89

2.47e-06

MAP-73884

Base Excision Repair

5 of 46

1.93

2.57

2.47e-06

MAP-73928

Depyrimidination

3 of 7

2.52

2.34

4.24e-05

MAP-110329

Cleavage of the damaged pyrimidine

3 of 7

2.52

2.34

4.24e-05

MAP-73894

DNA Repair

6 of 223

1.32

1.45

4.22e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0227

DNA damage

3 of 27

1.94

1.44

0.0014

KW-0234

DNA repair

2 of 21

1.87

0.78

0.0330

KW-0378

Hydrolase

4 of 271

1.06

0.58

0.0330

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000445

Helix-hairpin-helix motif

2 of 2

2.89

0.91

0.0224

IPR023170

Helix-hairpin-helix, base-excision DNA repair, C-terminal

2 of 4

2.59

0.86

0.0280

IPR003265

HhH-GPD domain

2 of 4

2.59

0.86

0.0280

IPR011257

DNA glycosylase

2 of 7

2.35

0.81

0.0335

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00478

Endonuclease III

2 of 3

2.72

1.29

0.0045

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (16%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Textmining

Cooccurrence

Databases

Coexpression

© STRING Consortium 2024

Credits

Access

Info

About