CCK81248.1 protein (Desulfobacula toluolica)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

CCK81248.1

Conserved uncharacterized protein. (121 aa)

Predicted Functional Partners:

CCK78470.1

0.522

CCK78267.1

0.508

CCK79453.1

0.413

CCK80857.1

0.403

CCK80895.1

0.403

CCK80914.1

0.403

CCK80935.1

0.403

Your Current Organism:

Desulfobacula toluolica

NCBI taxonomy Id: 651182
Other names: D. toluolica Tol2, Desulfobacula toluolica DSM 7467, Desulfobacula toluolica Tol2, Desulfobacula toluolica str. Tol2, Desulfobacula toluolica strain Tol2

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... functional annotations:

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCK78267.1	CCK78470.1	TOL2_C00970	TOL2_C03000	Reductive dehalogenase.	Uncharacterized protein; Signal peptide.	0.456
CCK78267.1	CCK81248.1	TOL2_C00970	TOL2_C30910	Reductive dehalogenase.	Conserved uncharacterized protein.	0.508
CCK78470.1	CCK78267.1	TOL2_C03000	TOL2_C00970	Uncharacterized protein; Signal peptide.	Reductive dehalogenase.	0.456
CCK78470.1	CCK81248.1	TOL2_C03000	TOL2_C30910	Uncharacterized protein; Signal peptide.	Conserved uncharacterized protein.	0.522
CCK79453.1	CCK81248.1	TOL2_C12900	TOL2_C30910	4Fe-4S ferredoxin domain protein.	Conserved uncharacterized protein.	0.413
CCK80857.1	CCK81248.1	TOL2_C26980	TOL2_C30910	Transposase, IS4 family.	Conserved uncharacterized protein.	0.403
CCK80895.1	CCK81248.1	TOL2_C27350	TOL2_C30910	Transposase, IS4 family.	Conserved uncharacterized protein.	0.403
CCK80914.1	CCK81248.1	TOL2_C27540	TOL2_C30910	Transposase, IS4 family.	Conserved uncharacterized protein.	0.403
CCK80935.1	CCK81248.1	TOL2_C27750	TOL2_C30910	Transposase, IS4 family.	Conserved uncharacterized protein.	0.403
CCK81248.1	CCK78267.1	TOL2_C30910	TOL2_C00970	Conserved uncharacterized protein.	Reductive dehalogenase.	0.508
CCK81248.1	CCK78470.1	TOL2_C30910	TOL2_C03000	Conserved uncharacterized protein.	Uncharacterized protein; Signal peptide.	0.522
CCK81248.1	CCK79453.1	TOL2_C30910	TOL2_C12900	Conserved uncharacterized protein.	4Fe-4S ferredoxin domain protein.	0.413
CCK81248.1	CCK80857.1	TOL2_C30910	TOL2_C26980	Conserved uncharacterized protein.	Transposase, IS4 family.	0.403
CCK81248.1	CCK80895.1	TOL2_C30910	TOL2_C27350	Conserved uncharacterized protein.	Transposase, IS4 family.	0.403
CCK81248.1	CCK80914.1	TOL2_C30910	TOL2_C27540	Conserved uncharacterized protein.	Transposase, IS4 family.	0.403
CCK81248.1	CCK80935.1	TOL2_C30910	TOL2_C27750	Conserved uncharacterized protein.	Transposase, IS4 family.	0.403

Network Stats

number of nodes:

11

number of edges:

42

average node degree:

7.64

avg. local clustering coefficient:

0.853

expected number of edges:

12

PPI enrichment p-value:

5.72e-12

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

10 of 109

1.23

1.79

2.77e-09

GO:0010467

Gene expression

11 of 178

1.05

1.37

2.77e-09

GO:0034641

Cellular nitrogen compound metabolic process

11 of 451

0.65

0.61

4.41e-06

GO:0044238

Primary metabolic process

11 of 611

0.52

0.45

8.82e-05

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

11 of 60

1.53

3.28

1.76e-14

GO:0019843

rRNA binding

4 of 33

1.35

1.0

0.0038

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005840

Ribosome

11 of 64

1.5

3.19

8.84e-15

GO:0044391

Ribosomal subunit

3 of 22

1.4

1.04

0.0034

GO:0015934

Large ribosomal subunit

2 of 10

1.56

0.84

0.0180

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:149

Ribosome

11 of 67

1.48

3.03

5.44e-14

CL:152

Structural molecule activity

9 of 49

1.53

2.92

2.07e-11

CL:155

Ribosome

8 of 42

1.54

2.77

4.87e-10

CL:156

Ribosome

7 of 34

1.58

2.64

9.34e-09

CL:158

Ribosome

5 of 22

1.62

2.11

4.21e-06

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

csy03010

Ribosome

10 of 57

1.51

3.03

6.96e-13

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0022627

Cytosolic small ribosomal subunit

3 of 6

1.96

1.85

0.00017

GOCC:0044391

Ribosomal subunit

4 of 14

1.72

1.73

0.00014

GOCC:0022626

Cytosolic ribosome

4 of 14

1.72

1.73

0.00014

GOCC:1990904

Ribonucleoprotein complex

5 of 33

1.44

1.48

0.00014

GOCC:0043232

Intracellular non-membrane-bounded organelle

6 of 88

1.1

1.07

0.00014

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

10 of 60

1.49

2.9

1.83e-12

KW-0699

rRNA-binding

4 of 30

1.39

1.21

0.00091

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