thlA protein (Desulfobacula toluolica) - STRING interaction network

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thlA

ThlA: acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (428 aa)

Predicted Functional Partners:

fadB

0.999

hbd

0.995

nifJ

0.940

gltA

0.937

gltA2

0.937

hmgL

0.928

mvaB

0.928

leuA2

0.927

leuA3

0.927

acsA

0.924

Your Current Organism:

Desulfobacula toluolica

NCBI taxonomy Id: 651182
Other names: D. toluolica Tol2, Desulfobacula toluolica DSM 7467, Desulfobacula toluolica Tol2, Desulfobacula toluolica str. Tol2, Desulfobacula toluolica strain Tol2

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
acsA	fadB	TOL2_C05220	TOL2_C01680	AcsA: acetyl-coenzyme A synthetase (acetate--CoA ligase); Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.	FadB: 3-hydroxyacyl-CoA dehydrogenase, NAD-binding.	0.416
acsA	gltA	TOL2_C05220	TOL2_C17330	AcsA: acetyl-coenzyme A synthetase (acetate--CoA ligase); Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.	GltA: citrate synthase; Belongs to the citrate synthase family.	0.932
acsA	gltA2	TOL2_C05220	TOL2_C38950	AcsA: acetyl-coenzyme A synthetase (acetate--CoA ligase); Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.	GltA2: citrate synthase, type II; Belongs to the citrate synthase family.	0.932
acsA	leuA2	TOL2_C05220	TOL2_C16630	AcsA: acetyl-coenzyme A synthetase (acetate--CoA ligase); Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.	LeuA2: 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.	0.911
acsA	leuA3	TOL2_C05220	TOL2_C16640	AcsA: acetyl-coenzyme A synthetase (acetate--CoA ligase); Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.	LeuA3, 2-isopropylmalate synthase 2.3.3.13; Belongs to the alpha-IPM synthase/homocitrate synthase family.	0.911
acsA	nifJ	TOL2_C05220	TOL2_C40810	AcsA: acetyl-coenzyme A synthetase (acetate--CoA ligase); Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.	NifJ: pyruvate-flavodoxin oxidoreductase.	0.950
acsA	thlA	TOL2_C05220	TOL2_C35070	AcsA: acetyl-coenzyme A synthetase (acetate--CoA ligase); Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.	ThlA: acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.924
fadB	acsA	TOL2_C01680	TOL2_C05220	FadB: 3-hydroxyacyl-CoA dehydrogenase, NAD-binding.	AcsA: acetyl-coenzyme A synthetase (acetate--CoA ligase); Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.	0.416
fadB	gltA	TOL2_C01680	TOL2_C17330	FadB: 3-hydroxyacyl-CoA dehydrogenase, NAD-binding.	GltA: citrate synthase; Belongs to the citrate synthase family.	0.752
fadB	gltA2	TOL2_C01680	TOL2_C38950	FadB: 3-hydroxyacyl-CoA dehydrogenase, NAD-binding.	GltA2: citrate synthase, type II; Belongs to the citrate synthase family.	0.752
fadB	hbd	TOL2_C01680	TOL2_C06780	FadB: 3-hydroxyacyl-CoA dehydrogenase, NAD-binding.	Hbd: 3-hydroxybutyryl-CoA dehyrogenase.	0.947
fadB	hmgL	TOL2_C01680	TOL2_C06710	FadB: 3-hydroxyacyl-CoA dehydrogenase, NAD-binding.	HmgL: predicted hydroxymethylglutaryl-CoA lyase.	0.513
fadB	leuA2	TOL2_C01680	TOL2_C16630	FadB: 3-hydroxyacyl-CoA dehydrogenase, NAD-binding.	LeuA2: 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.	0.513
fadB	leuA3	TOL2_C01680	TOL2_C16640	FadB: 3-hydroxyacyl-CoA dehydrogenase, NAD-binding.	LeuA3, 2-isopropylmalate synthase 2.3.3.13; Belongs to the alpha-IPM synthase/homocitrate synthase family.	0.513
fadB	mvaB	TOL2_C01680	TOL2_C26240	FadB: 3-hydroxyacyl-CoA dehydrogenase, NAD-binding.	MvaB: hydroxymehtylglutaryl-CoA lyase.	0.513
fadB	nifJ	TOL2_C01680	TOL2_C40810	FadB: 3-hydroxyacyl-CoA dehydrogenase, NAD-binding.	NifJ: pyruvate-flavodoxin oxidoreductase.	0.603
fadB	thlA	TOL2_C01680	TOL2_C35070	FadB: 3-hydroxyacyl-CoA dehydrogenase, NAD-binding.	ThlA: acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.999
gltA	acsA	TOL2_C17330	TOL2_C05220	GltA: citrate synthase; Belongs to the citrate synthase family.	AcsA: acetyl-coenzyme A synthetase (acetate--CoA ligase); Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.	0.932
gltA	fadB	TOL2_C17330	TOL2_C01680	GltA: citrate synthase; Belongs to the citrate synthase family.	FadB: 3-hydroxyacyl-CoA dehydrogenase, NAD-binding.	0.752
gltA	gltA2	TOL2_C17330	TOL2_C38950	GltA: citrate synthase; Belongs to the citrate synthase family.	GltA2: citrate synthase, type II; Belongs to the citrate synthase family.	0.922

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