STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
queF7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). (276 aa)    
Predicted Functional Partners:
SDT33361.1
preQ(0) biosynthesis protein QueC.
 
 
 0.992
queE
7-carboxy-7-deazaguanine synthase; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
  
  
 0.945
queD
6-pyruvoyltetrahydropterin/6- carboxytetrahydropterin synthase.
  
  
 0.929
SDT35942.1
Hypothetical protein.
  
  
 0.853
SDS12206.1
Uncharacterized copper-binding protein, cupredoxin-like subfamily.
     
 0.835
tgt
tRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the [...]
 
  
 0.797
queA
S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
 
  
 0.706
SDS99676.1
DNA-binding transcriptional regulator, MerR family.
 
  
  0.705
cadR
Cd(II)/Pb(II)-responsive transcriptional regulator.
    
  0.665
soxR
MerR family transcriptional regulator, redox-sensitive transcriptional activator SoxR.
    
  0.664
Your Current Organism:
Pseudomonas cedrina
NCBI taxonomy Id: 651740
Other names: CFML 96-198, CIP 105541, DSM 17516, P. cedrina, Pseudomonas cedrella, Pseudomonas cedrina corrig. Dabboussi et al. 2002 emend. Behrendt et al. 2009, Pseudomonas sp. H-R, Pseudomonas sp. HG-K2, Pseudomonas sp. LB-C, Pseudomonas sp. LB-Z10, Pseudomonas sp. LB-Z3
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