node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SDS48989.1 | SDS49402.1 | SAMN04490182_1660 | SAMN04490182_1668 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Cobaltochelatase CobN. | 0.607 |
SDS48989.1 | SDT23372.1 | SAMN04490182_1660 | SAMN04490182_3723 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Adenosylcobinamide kinase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. | 0.599 |
SDS48989.1 | SDT23431.1 | SAMN04490182_1660 | SAMN04490182_3726 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | L-threonine O-3-phosphate decarboxylase. | 0.449 |
SDS48989.1 | SDT33928.1 | SAMN04490182_1660 | SAMN04490182_4180 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | cob(I)alamin adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family. | 0.830 |
SDS48989.1 | cobB-2 | SAMN04490182_1660 | SAMN04490182_3729 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) /cobyrinate a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.451 |
SDS48989.1 | cobD | SAMN04490182_1660 | SAMN04490182_3727 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Adenosylcobinamide-phosphate synthase; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.477 |
SDS48989.1 | cobO | SAMN04490182_1660 | SAMN04490182_3730 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | cob(I)yrinic acid a,c-diamide adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. | 0.599 |
SDS48989.1 | cobQ | SAMN04490182_1660 | SAMN04490182_3725 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Adenosylcobyric acid synthase (glutamine-hydrolysing); Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.517 |
SDS48989.1 | cobS | SAMN04490182_1660 | SAMN04490182_3720 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Cobalamin-5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.557 |
SDS49402.1 | SDS48989.1 | SAMN04490182_1668 | SAMN04490182_1660 | Cobaltochelatase CobN. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.607 |
SDS49402.1 | SDT23372.1 | SAMN04490182_1668 | SAMN04490182_3723 | Cobaltochelatase CobN. | Adenosylcobinamide kinase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. | 0.798 |
SDS49402.1 | SDT23431.1 | SAMN04490182_1668 | SAMN04490182_3726 | Cobaltochelatase CobN. | L-threonine O-3-phosphate decarboxylase. | 0.715 |
SDS49402.1 | SDT33928.1 | SAMN04490182_1668 | SAMN04490182_4180 | Cobaltochelatase CobN. | cob(I)alamin adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family. | 0.962 |
SDS49402.1 | cobB-2 | SAMN04490182_1668 | SAMN04490182_3729 | Cobaltochelatase CobN. | Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) /cobyrinate a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.995 |
SDS49402.1 | cobD | SAMN04490182_1668 | SAMN04490182_3727 | Cobaltochelatase CobN. | Adenosylcobinamide-phosphate synthase; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.735 |
SDS49402.1 | cobO | SAMN04490182_1668 | SAMN04490182_3730 | Cobaltochelatase CobN. | cob(I)yrinic acid a,c-diamide adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. | 0.982 |
SDS49402.1 | cobQ | SAMN04490182_1668 | SAMN04490182_3725 | Cobaltochelatase CobN. | Adenosylcobyric acid synthase (glutamine-hydrolysing); Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.657 |
SDS49402.1 | cobS | SAMN04490182_1668 | SAMN04490182_3720 | Cobaltochelatase CobN. | Cobalamin-5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.554 |
SDT23372.1 | SDS48989.1 | SAMN04490182_3723 | SAMN04490182_1660 | Adenosylcobinamide kinase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.599 |
SDT23372.1 | SDS49402.1 | SAMN04490182_3723 | SAMN04490182_1668 | Adenosylcobinamide kinase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. | Cobaltochelatase CobN. | 0.798 |