| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ALP40448.1 | ltaA | WL1483_4503 | WL1483_125 | Homogentisate 1, 2-dioxygenase. | L-allo-threonine aldolase. | 0.469 |
| ALP40448.1 | maiA | WL1483_4503 | WL1483_2230 | Homogentisate 1, 2-dioxygenase. | Maleylacetoacetate isomerase. | 0.994 |
| ALP40448.1 | vllY | WL1483_4503 | WL1483_447 | Homogentisate 1, 2-dioxygenase. | 4-hydroxyphenylpyruvate dioxygenase. | 0.999 |
| ALP43225.1 | gcvP | WL1483_4938 | WL1483_1243 | Short-chain alcohol dehydrogenase family protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.533 |
| ALP43225.1 | kbl | WL1483_4938 | WL1483_4223 | Short-chain alcohol dehydrogenase family protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | 0.900 |
| ALP43225.1 | ltaA | WL1483_4938 | WL1483_125 | Short-chain alcohol dehydrogenase family protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | L-allo-threonine aldolase. | 0.914 |
| gcvP | ALP43225.1 | WL1483_1243 | WL1483_4938 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Short-chain alcohol dehydrogenase family protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.533 |
| gcvP | gltB | WL1483_1243 | WL1483_2763 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Glutamate synthase subunit alpha. | 0.910 |
| gcvP | glyA | WL1483_1243 | WL1483_809 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.996 |
| gcvP | kbl | WL1483_1243 | WL1483_4223 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | 0.943 |
| gcvP | ltaA | WL1483_1243 | WL1483_125 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | L-allo-threonine aldolase. | 0.957 |
| gltB | gcvP | WL1483_2763 | WL1483_1243 | Glutamate synthase subunit alpha. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.910 |
| gltB | glyA | WL1483_2763 | WL1483_809 | Glutamate synthase subunit alpha. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.511 |
| gltB | guaB | WL1483_2763 | WL1483_2534 | Glutamate synthase subunit alpha. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.633 |
| gltB | kbl | WL1483_2763 | WL1483_4223 | Glutamate synthase subunit alpha. | 2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | 0.422 |
| gltB | ltaA | WL1483_2763 | WL1483_125 | Glutamate synthase subunit alpha. | L-allo-threonine aldolase. | 0.476 |
| gltB | ychF | WL1483_2763 | WL1483_4309 | Glutamate synthase subunit alpha. | GTP-binding protein YchF; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. | 0.587 |
| glyA | gcvP | WL1483_809 | WL1483_1243 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.996 |
| glyA | gltB | WL1483_809 | WL1483_2763 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Glutamate synthase subunit alpha. | 0.511 |
| glyA | guaB | WL1483_809 | WL1483_2534 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.758 |
