node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALP40381.1 | clcA | WL1483_962 | WL1483_505 | Hypothetical protein. | H(+)/Cl(-) exchange transporter ClcA. | 0.654 |
ALP40381.1 | erpA | WL1483_962 | WL1483_1467 | Hypothetical protein. | Iron-sulfur cluster insertion protein ErpA; Required for insertion of 4Fe-4S clusters for at least IspG. | 0.646 |
ALP41519.1 | erpA | WL1483_4673 | WL1483_1467 | Aminomethyltransferase. | Iron-sulfur cluster insertion protein ErpA; Required for insertion of 4Fe-4S clusters for at least IspG. | 0.630 |
ALP41519.1 | grxD | WL1483_4673 | WL1483_3970 | Aminomethyltransferase. | Glutaredoxin-like protein; Belongs to the glutaredoxin family. Monothiol subfamily. | 0.509 |
ALP41519.1 | iscS | WL1483_4673 | WL1483_4347 | Aminomethyltransferase. | Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. | 0.409 |
ALP41519.1 | nfuA | WL1483_4673 | WL1483_550 | Aminomethyltransferase. | Fe/S biogenesis protein NfuA; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. | 0.626 |
clcA | ALP40381.1 | WL1483_505 | WL1483_962 | H(+)/Cl(-) exchange transporter ClcA. | Hypothetical protein. | 0.654 |
clcA | erpA | WL1483_505 | WL1483_1467 | H(+)/Cl(-) exchange transporter ClcA. | Iron-sulfur cluster insertion protein ErpA; Required for insertion of 4Fe-4S clusters for at least IspG. | 0.534 |
djlA | erpA | WL1483_1632 | WL1483_1467 | Co-chaperone DjlA; Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB/RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host. | Iron-sulfur cluster insertion protein ErpA; Required for insertion of 4Fe-4S clusters for at least IspG. | 0.620 |
djlA | grxD | WL1483_1632 | WL1483_3970 | Co-chaperone DjlA; Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB/RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host. | Glutaredoxin-like protein; Belongs to the glutaredoxin family. Monothiol subfamily. | 0.461 |
djlA | iscS | WL1483_1632 | WL1483_4347 | Co-chaperone DjlA; Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB/RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host. | Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. | 0.769 |
djlA | iscU | WL1483_1632 | WL1483_289 | Co-chaperone DjlA; Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB/RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host. | Scaffold protein; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | 0.960 |
djlA | nfuA | WL1483_1632 | WL1483_550 | Co-chaperone DjlA; Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB/RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host. | Fe/S biogenesis protein NfuA; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. | 0.876 |
erpA | ALP40381.1 | WL1483_1467 | WL1483_962 | Iron-sulfur cluster insertion protein ErpA; Required for insertion of 4Fe-4S clusters for at least IspG. | Hypothetical protein. | 0.646 |
erpA | ALP41519.1 | WL1483_1467 | WL1483_4673 | Iron-sulfur cluster insertion protein ErpA; Required for insertion of 4Fe-4S clusters for at least IspG. | Aminomethyltransferase. | 0.630 |
erpA | clcA | WL1483_1467 | WL1483_505 | Iron-sulfur cluster insertion protein ErpA; Required for insertion of 4Fe-4S clusters for at least IspG. | H(+)/Cl(-) exchange transporter ClcA. | 0.534 |
erpA | djlA | WL1483_1467 | WL1483_1632 | Iron-sulfur cluster insertion protein ErpA; Required for insertion of 4Fe-4S clusters for at least IspG. | Co-chaperone DjlA; Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB/RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host. | 0.620 |
erpA | fdx | WL1483_1467 | WL1483_2691 | Iron-sulfur cluster insertion protein ErpA; Required for insertion of 4Fe-4S clusters for at least IspG. | Ferredoxin. | 0.490 |
erpA | grxD | WL1483_1467 | WL1483_3970 | Iron-sulfur cluster insertion protein ErpA; Required for insertion of 4Fe-4S clusters for at least IspG. | Glutaredoxin-like protein; Belongs to the glutaredoxin family. Monothiol subfamily. | 0.639 |
erpA | hscB | WL1483_1467 | WL1483_2843 | Iron-sulfur cluster insertion protein ErpA; Required for insertion of 4Fe-4S clusters for at least IspG. | Co-chaperone protein hscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | 0.727 |