A0A2C9KE98 protein (Biomphalaria glabrata) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

A0A2C9KE98

Uncharacterized protein. (206 aa)

Predicted Functional Partners:

A0A2C9JVW6

0.903

A0A2C9K688

0.901

A0A2C9JTD6

0.900

A0A2C9K4V7

0.900

A0A2C9JVA2

0.797

A0A2C9JSS9

0.796

A0A2C9JPD9

0.713

A0A2C9K0T6

0.709

A0A2C9KEG1

0.497

A0A2C9JD35

0.459

Your Current Organism:

Biomphalaria glabrata

NCBI taxonomy Id: 6526
Other names: Australorbis glabratus, B. glabrata, Planorbis glabratus, bloodfluke planorb

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A2C9JD35	A0A2C9JTD6	Uncharacterized protein.	Uncharacterized protein.	0.803
A0A2C9JD35	A0A2C9JVA2	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.629
A0A2C9JD35	A0A2C9K4V7	Uncharacterized protein.	HTH myb-type domain-containing protein.	0.585
A0A2C9JD35	A0A2C9K688	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.682
A0A2C9JD35	A0A2C9KE98	Uncharacterized protein.	Uncharacterized protein.	0.459
A0A2C9JD35	A0A2C9KEG1	Uncharacterized protein.	Rtf2 domain-containing protein.	0.573
A0A2C9JPD9	A0A2C9KE98	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase; Belongs to the glycosyltransferase 43 family.	Uncharacterized protein.	0.713
A0A2C9JSS9	A0A2C9KE98	Uncharacterized protein.	Uncharacterized protein.	0.796
A0A2C9JTD6	A0A2C9JD35	Uncharacterized protein.	Uncharacterized protein.	0.803
A0A2C9JTD6	A0A2C9JVA2	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.952
A0A2C9JTD6	A0A2C9JVW6	Uncharacterized protein.	Uncharacterized protein.	0.993
A0A2C9JTD6	A0A2C9K4V7	Uncharacterized protein.	HTH myb-type domain-containing protein.	0.994
A0A2C9JTD6	A0A2C9K688	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.994
A0A2C9JTD6	A0A2C9KE98	Uncharacterized protein.	Uncharacterized protein.	0.900
A0A2C9JVA2	A0A2C9JD35	WD_REPEATS_REGION domain-containing protein.	Uncharacterized protein.	0.629
A0A2C9JVA2	A0A2C9JTD6	WD_REPEATS_REGION domain-containing protein.	Uncharacterized protein.	0.952
A0A2C9JVA2	A0A2C9JVW6	WD_REPEATS_REGION domain-containing protein.	Uncharacterized protein.	0.937
A0A2C9JVA2	A0A2C9K4V7	WD_REPEATS_REGION domain-containing protein.	HTH myb-type domain-containing protein.	0.962
A0A2C9JVA2	A0A2C9KE98	WD_REPEATS_REGION domain-containing protein.	Uncharacterized protein.	0.797
A0A2C9JVW6	A0A2C9JTD6	Uncharacterized protein.	Uncharacterized protein.	0.993

page 1 of 3

Network Stats

number of nodes:

3

number of edges:

2

average node degree:

1.33

avg. local clustering coefficient:

0.667

expected number of edges:

2

PPI enrichment p-value:

0.533

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006470

Protein dephosphorylation

9 of 403

2.33

7.26

5.46e-17

GO:0031348

Negative regulation of defense response

5 of 171

2.45

4.2

5.68e-09

GO:0035556

Intracellular signal transduction

7 of 1534

1.64

2.66

3.74e-08

GO:0006796

Phosphate-containing compound metabolic process

11 of 8535

1.09

1.47

1.70e-09

GO:0036211

Protein modification process

11 of 12717

0.92

1.04

5.84e-08

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0033550

MAP kinase tyrosine phosphatase activity

5 of 6

3.9

8.08

2.74e-15

GO:0004725

Protein tyrosine phosphatase activity

6 of 68

2.93

7.1

4.17e-14

GO:0004721

Phosphoprotein phosphatase activity

9 of 558

2.19

6.43

5.43e-16

GO:0019900

Kinase binding

5 of 401

2.08

3.25

1.16e-07

GO:0017018

Myosin phosphatase activity

3 of 408

1.85

1.32

0.0022

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0110165

Cellular anatomical entity

11 of 19699

0.73

0.69

9.29e-06

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:16211

MAP kinase phosphatase activity, and MAP kinase activity

6 of 32

3.25

7.61

1.05e-14

CL:15979

MAPK cascade, and MAP kinase phosphatase activity

7 of 153

2.64

6.87

2.80e-14

CL:16212

MAP kinase phosphatase activity, and MAP kinase activity

5 of 27

3.25

6.53

1.12e-12

CL:16213

MAP kinase phosphatase activity, and MAP kinase activity

4 of 22

3.24

4.91

1.15e-09

CL:40594

Mixed, incl. Positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response, and bZIP transcription factor RISBZ3/4/5

3 of 13

3.34

3.47

5.25e-07

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-162582

Signal Transduction

8 of 4506

1.23

1.53

1.49e-06

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0044099

Polar tube

5 of 6

3.9

8.03

3.33e-15

GOCC:0020018

Ciliary pocket membrane

5 of 6

3.9

8.03

3.33e-15

GOCC:0005952

cAMP-dependent protein kinase complex

3 of 12

3.38

3.92

8.07e-08

GOCC:0110165

Cellular anatomical entity

7 of 8339

0.9

0.77

0.00068

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0904

Protein phosphatase

3 of 187

2.19

1.95

0.00017

KW-0378

Hydrolase

8 of 3510

1.34

1.91

8.41e-08

KW-0460

Magnesium

3 of 742

1.59

1.02

0.0067

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00069

Protein kinase domain

4 of 474

1.91

1.65

0.00044

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000242

Tyrosine-specific protein phosphatase, PTPase domain

5 of 6

3.9

7.62

1.89e-14

IPR003595

Protein-tyrosine phosphatase, catalytic

5 of 8

3.78

7.52

2.63e-14

IPR000387

Tyrosine-specific protein phosphatases domain

5 of 67

2.85

5.19

1.90e-10

IPR029021

Protein-tyrosine phosphatase-like

5 of 99

2.68

4.75

9.35e-10

IPR018490

Cyclic nucleotide-binding domain superfamily

3 of 100

2.46

1.91

0.00027

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00194

Protein tyrosine phosphatase, catalytic domain

5 of 6

3.9

8.25

1.32e-15

SM00332

Serine/threonine phosphatases, family 2C, catalytic domain

3 of 40

2.86

2.97

3.46e-06

SM00100

Cyclic nucleotide-monophosphate binding domain

3 of 91

2.5

2.45

2.50e-05

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