A0A2C9L7B2 protein (Biomphalaria glabrata) - STRING interaction network

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second shell of interactors

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Known Interactions

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Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

A0A2C9L7B2

Cyclic nucleotide-binding domain-containing protein. (519 aa)

Predicted Functional Partners:

A0A2C9K5R3

0.920

A0A2C9JU35

0.513

A0A2C9LZQ8

0.505

A0A2C9JIA6

0.432

A0A2C9KT85

0.432

A0A2C9K8A9

0.429

Your Current Organism:

Biomphalaria glabrata

NCBI taxonomy Id: 6526
Other names: Australorbis glabratus, B. glabrata, Planorbis glabratus, bloodfluke planorb

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A2C9JIA6	A0A2C9K8A9	Plug_translocon domain-containing protein.	Ion_trans domain-containing protein.	0.432
A0A2C9JIA6	A0A2C9KT85	Plug_translocon domain-containing protein.	Uncharacterized protein.	0.561
A0A2C9JIA6	A0A2C9L7B2	Plug_translocon domain-containing protein.	Cyclic nucleotide-binding domain-containing protein.	0.432
A0A2C9JU35	A0A2C9K5R3	Uncharacterized protein.	Cyclic nucleotide-binding domain-containing protein.	0.861
A0A2C9JU35	A0A2C9K8A9	Uncharacterized protein.	Ion_trans domain-containing protein.	0.513
A0A2C9JU35	A0A2C9L7B2	Uncharacterized protein.	Cyclic nucleotide-binding domain-containing protein.	0.513
A0A2C9K5R3	A0A2C9JU35	Cyclic nucleotide-binding domain-containing protein.	Uncharacterized protein.	0.861
A0A2C9K5R3	A0A2C9K8A9	Cyclic nucleotide-binding domain-containing protein.	Ion_trans domain-containing protein.	0.912
A0A2C9K5R3	A0A2C9L7B2	Cyclic nucleotide-binding domain-containing protein.	Cyclic nucleotide-binding domain-containing protein.	0.920
A0A2C9K8A9	A0A2C9JIA6	Ion_trans domain-containing protein.	Plug_translocon domain-containing protein.	0.432
A0A2C9K8A9	A0A2C9JU35	Ion_trans domain-containing protein.	Uncharacterized protein.	0.513
A0A2C9K8A9	A0A2C9K5R3	Ion_trans domain-containing protein.	Cyclic nucleotide-binding domain-containing protein.	0.912
A0A2C9K8A9	A0A2C9KT85	Ion_trans domain-containing protein.	Uncharacterized protein.	0.432
A0A2C9K8A9	A0A2C9L7B2	Ion_trans domain-containing protein.	Cyclic nucleotide-binding domain-containing protein.	0.429
A0A2C9K8A9	A0A2C9LZQ8	Ion_trans domain-containing protein.	Sec8_exocyst domain-containing protein.	0.505
A0A2C9KT85	A0A2C9JIA6	Uncharacterized protein.	Plug_translocon domain-containing protein.	0.561
A0A2C9KT85	A0A2C9K8A9	Uncharacterized protein.	Ion_trans domain-containing protein.	0.432
A0A2C9KT85	A0A2C9L7B2	Uncharacterized protein.	Cyclic nucleotide-binding domain-containing protein.	0.432
A0A2C9L7B2	A0A2C9JIA6	Cyclic nucleotide-binding domain-containing protein.	Plug_translocon domain-containing protein.	0.432
A0A2C9L7B2	A0A2C9JU35	Cyclic nucleotide-binding domain-containing protein.	Uncharacterized protein.	0.513

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

31

average node degree:

5.64

avg. local clustering coefficient:

0.429

expected number of edges:

16

PPI enrichment p-value:

0.000631

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0044205

De novo UMP biosynthetic process

5 of 8

2.3

3.42

1.53e-07

GO:0009112

Nucleobase metabolic process

5 of 19

1.93

2.88

3.56e-07

GO:0046112

Nucleobase biosynthetic process

4 of 9

2.16

2.81

2.05e-06

GO:0009156

Ribonucleoside monophosphate biosynthetic process

6 of 33

1.77

2.75

1.53e-07

GO:0009084

Glutamine family amino acid biosynthetic process

5 of 23

1.85

2.68

6.36e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004088

Carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity

2 of 2

2.51

0.8

0.0355

GO:0016743

Carboxyl- or carbamoyltransferase activity

2 of 4

2.21

0.79

0.0355

GO:0016597

Amino acid binding

2 of 3

2.33

0.79

0.0355

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

10 of 1079

0.48

0.36

0.0075

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:768

De novo UMP biosynthetic process

5 of 8

2.3

3.72

3.27e-08

CL:715

Ribonucleoside monophosphate metabolic process, and IMP dehydrogenase activity

7 of 37

1.79

3.17

6.78e-09

CL:1254

Glutamine family amino acid biosynthetic process, and Glycine catabolic process

3 of 36

1.43

0.75

0.0249

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

tbi00250

Alanine, aspartate and glutamate metabolism

6 of 27

1.86

3.19

1.86e-08

tbi00240

Pyrimidine metabolism

6 of 27

1.86

3.19

1.86e-08

tbi01100

Metabolic pathways

11 of 670

0.72

4.15e-07

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0665

Pyrimidine biosynthesis

5 of 10

2.21

3.52

5.72e-08

KW-0055

Arginine biosynthesis

3 of 9

2.03

1.69

0.00047

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02729

Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain

2 of 2

2.51

0.85

0.0284

PF00185

Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain

2 of 2

2.51

0.85

0.0284

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