node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SDT60202.1 | SDT61619.1 | SAMN05216490_4260 | SAMN05216490_4347 | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase. | Aspartate kinase. | 0.860 |
SDT60202.1 | SDT67061.1 | SAMN05216490_4260 | SAMN05216490_4756 | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase. | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | 0.906 |
SDT60202.1 | SDT67066.1 | SAMN05216490_4260 | SAMN05216490_4757 | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.906 |
SDT60202.1 | metK | SAMN05216490_4260 | SAMN05216490_0280 | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.914 |
SDT60202.1 | metN | SAMN05216490_4260 | SAMN05216490_0111 | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase. | D-methionine transport system ATP-binding protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. | 0.531 |
SDT61619.1 | SDT60202.1 | SAMN05216490_4347 | SAMN05216490_4260 | Aspartate kinase. | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase. | 0.860 |
SDT61619.1 | SDT67061.1 | SAMN05216490_4347 | SAMN05216490_4756 | Aspartate kinase. | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | 0.951 |
SDT61619.1 | SDT67066.1 | SAMN05216490_4347 | SAMN05216490_4757 | Aspartate kinase. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.981 |
SDT61619.1 | glyA | SAMN05216490_4347 | SAMN05216490_0361 | Aspartate kinase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.793 |
SDT61619.1 | metE | SAMN05216490_4347 | SAMN05216490_3426 | Aspartate kinase. | Methionine synthase (B12-independent); Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.949 |
SDT61619.1 | metK | SAMN05216490_4347 | SAMN05216490_0280 | Aspartate kinase. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.646 |
SDT61619.1 | metN | SAMN05216490_4347 | SAMN05216490_0111 | Aspartate kinase. | D-methionine transport system ATP-binding protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. | 0.648 |
SDT67061.1 | SDT60202.1 | SAMN05216490_4756 | SAMN05216490_4260 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase. | 0.906 |
SDT67061.1 | SDT61619.1 | SAMN05216490_4756 | SAMN05216490_4347 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Aspartate kinase. | 0.951 |
SDT67061.1 | SDT67066.1 | SAMN05216490_4756 | SAMN05216490_4757 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.999 |
SDT67061.1 | folD | SAMN05216490_4756 | SAMN05216490_1769 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.922 |
SDT67061.1 | gcvT | SAMN05216490_4756 | SAMN05216490_4339 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.923 |
SDT67061.1 | glyA | SAMN05216490_4756 | SAMN05216490_0361 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.939 |
SDT67061.1 | metE | SAMN05216490_4756 | SAMN05216490_3426 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Methionine synthase (B12-independent); Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.940 |
SDT67061.1 | metK | SAMN05216490_4756 | SAMN05216490_0280 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.911 |