node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EHM92413.1 | EHM94419.1 | HMPREF0975_02279 | HMPREF0975_01526 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Dihydrofolate reductase. | 0.715 |
EHM92413.1 | EHM95528.1 | HMPREF0975_02279 | HMPREF0975_00392 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Hypothetical protein. | 0.571 |
EHM92413.1 | EHM95740.1 | HMPREF0975_02279 | HMPREF0975_00191 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Hypothetical protein. | 0.999 |
EHM92413.1 | glyA | HMPREF0975_02279 | HMPREF0975_01455 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.620 |
EHM92413.1 | purU | HMPREF0975_02279 | HMPREF0975_01439 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.441 |
EHM92413.1 | thyA | HMPREF0975_02279 | HMPREF0975_01527 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.795 |
EHM94419.1 | EHM92413.1 | HMPREF0975_01526 | HMPREF0975_02279 | Dihydrofolate reductase. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.715 |
EHM94419.1 | EHM94421.1 | HMPREF0975_01526 | HMPREF0975_01528 | Dihydrofolate reductase. | Hypothetical protein. | 0.799 |
EHM94419.1 | EHM95528.1 | HMPREF0975_01526 | HMPREF0975_00392 | Dihydrofolate reductase. | Hypothetical protein. | 0.763 |
EHM94419.1 | EHM95740.1 | HMPREF0975_01526 | HMPREF0975_00191 | Dihydrofolate reductase. | Hypothetical protein. | 0.973 |
EHM94419.1 | fhs | HMPREF0975_01526 | HMPREF0975_01684 | Dihydrofolate reductase. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.903 |
EHM94419.1 | fmt | HMPREF0975_01526 | HMPREF0975_00978 | Dihydrofolate reductase. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.933 |
EHM94419.1 | glyA | HMPREF0975_01526 | HMPREF0975_01455 | Dihydrofolate reductase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.907 |
EHM94419.1 | purH | HMPREF0975_01526 | HMPREF0975_00389 | Dihydrofolate reductase. | Hypothetical protein. | 0.901 |
EHM94419.1 | purU | HMPREF0975_01526 | HMPREF0975_01439 | Dihydrofolate reductase. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.897 |
EHM94419.1 | thyA | HMPREF0975_01526 | HMPREF0975_01527 | Dihydrofolate reductase. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.999 |
EHM94421.1 | EHM94419.1 | HMPREF0975_01528 | HMPREF0975_01526 | Hypothetical protein. | Dihydrofolate reductase. | 0.799 |
EHM94421.1 | thyA | HMPREF0975_01528 | HMPREF0975_01527 | Hypothetical protein. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.799 |
EHM95528.1 | EHM92413.1 | HMPREF0975_00392 | HMPREF0975_02279 | Hypothetical protein. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.571 |
EHM95528.1 | EHM94419.1 | HMPREF0975_00392 | HMPREF0975_01526 | Hypothetical protein. | Dihydrofolate reductase. | 0.763 |