BN9_013180 protein (Albugo candida) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

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[Homology]

Score

BN9_013180

TPR_REGION domain-containing protein. (411 aa)

Predicted Functional Partners:

BN9_100660

0.906

BN9_048910

0.898

BN9_085780

0.871

BN9_029370

0.828

BN9_027950

0.818

BN9_037500

0.818

BN9_037520

0.818

BN9_037530

0.818

BN9_037510

0.818

BN9_084210

0.818

Your Current Organism:

Albugo candida

NCBI taxonomy Id: 65357
Other names: A. candida, Aecidium candidum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BN9_013180	BN9_027950	A0A024G196	A0A024G5H9	TPR_REGION domain-containing protein.	Uncharacterized protein.	0.818
BN9_013180	BN9_029370	A0A024G196	A0A024G658	TPR_REGION domain-containing protein.	AMP-binding domain-containing protein.	0.828
BN9_013180	BN9_037500	A0A024G196	A0A024G7Y1	TPR_REGION domain-containing protein.	TPR_REGION domain-containing protein.	0.818
BN9_013180	BN9_037510	A0A024G196	A0A024G9H8	TPR_REGION domain-containing protein.	TPR_REGION domain-containing protein.	0.818
BN9_013180	BN9_037520	A0A024G196	A0A024G8A2	TPR_REGION domain-containing protein.	TPR_REGION domain-containing protein.	0.818
BN9_013180	BN9_037530	A0A024G196	A0A024G8J4	TPR_REGION domain-containing protein.	TPR_REGION domain-containing protein.	0.818
BN9_013180	BN9_048910	A0A024G196	A0A024GCP7	TPR_REGION domain-containing protein.	Uncharacterized protein.	0.898
BN9_013180	BN9_084210	A0A024G196	A0A024GL41	TPR_REGION domain-containing protein.	Uncharacterized protein.	0.818
BN9_013180	BN9_085780	A0A024G196	A0A024GM19	TPR_REGION domain-containing protein.	Uncharacterized protein.	0.871
BN9_013180	BN9_100660	A0A024G196	A0A024GPQ2	TPR_REGION domain-containing protein.	Uncharacterized protein.	0.906
BN9_027950	BN9_013180	A0A024G5H9	A0A024G196	Uncharacterized protein.	TPR_REGION domain-containing protein.	0.818
BN9_027950	BN9_037500	A0A024G5H9	A0A024G7Y1	Uncharacterized protein.	TPR_REGION domain-containing protein.	0.818
BN9_027950	BN9_037510	A0A024G5H9	A0A024G9H8	Uncharacterized protein.	TPR_REGION domain-containing protein.	0.818
BN9_027950	BN9_037520	A0A024G5H9	A0A024G8A2	Uncharacterized protein.	TPR_REGION domain-containing protein.	0.818
BN9_027950	BN9_037530	A0A024G5H9	A0A024G8J4	Uncharacterized protein.	TPR_REGION domain-containing protein.	0.818
BN9_029370	BN9_013180	A0A024G658	A0A024G196	AMP-binding domain-containing protein.	TPR_REGION domain-containing protein.	0.828
BN9_029370	BN9_037500	A0A024G658	A0A024G7Y1	AMP-binding domain-containing protein.	TPR_REGION domain-containing protein.	0.890
BN9_029370	BN9_037510	A0A024G658	A0A024G9H8	AMP-binding domain-containing protein.	TPR_REGION domain-containing protein.	0.890
BN9_029370	BN9_037520	A0A024G658	A0A024G8A2	AMP-binding domain-containing protein.	TPR_REGION domain-containing protein.	0.890
BN9_029370	BN9_037530	A0A024G658	A0A024G8J4	AMP-binding domain-containing protein.	TPR_REGION domain-containing protein.	0.890

page 1 of 4

Network Stats

number of nodes:

5

number of edges:

5

average node degree:

2

avg. local clustering coefficient:

0.833

expected number of edges:

4

PPI enrichment p-value:

0.375

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:2000169

Regulation of peptidyl-cysteine S-nitrosylation

2 of 4

3.16

1.37

0.0125

GO:0098974

Postsynaptic actin cytoskeleton organization

2 of 7

2.92

1.31

0.0150

GO:0042730

Fibrinolysis

2 of 9

2.81

1.31

0.0150

GO:0060307

Regulation of ventricular cardiac muscle cell membrane repolarization

2 of 11

2.73

1.3

0.0150

GO:1901385

Regulation of voltage-gated calcium channel activity

2 of 21

2.44

1.12

0.0264

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0050998

Nitric-oxide synthase binding

2 of 9

2.81

1.34

0.0134

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0002102

Podosome

2 of 13

2.65

1.35

0.0127

GO:0033017

Sarcoplasmic reticulum membrane

2 of 18

2.51

1.34

0.0127

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:32351978

(2020) Erysipelothrix Spp.: Past, Present, and Future Directions in Vaccine Research.

2 of 3

3.29

2.04

0.0015

PMID:38254464

(2024) Pathogenic Potential of Coagulase-Positive Staphylococcus Strains Isolated from Aviary Capercaillies and Free-Living Birds in Southeastern Poland.

2 of 4

3.16

2.03

0.0015

PMID:31078554

(2019) How Environmental Fungi Cause a Range of Clinical Outcomes in Susceptible Hosts.

2 of 9

2.81

1.83

0.0027

PMID:22229971

(2012) Biology and pathogenesis of Acanthamoeba.

2 of 10

2.77

1.83

0.0027

PMID:37889324

(2023) Gallibacterium anatis infection in poultry: a comprehensive review.

2 of 13

2.65

1.77

0.0031

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:26252

Mixed, incl. Regulation of peptidyl-cysteine S-nitrosylation, and PKHG1/2/3, pleckstrin homology (PH) domain

3 of 6

3.16

3.77

5.32e-06

CL:19214

Mixed, incl. Fibrinolysis, and Fibrinogen

2 of 12

2.69

1.65

0.0047

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8964041

LDL remodeling

2 of 9

2.81

1.48

0.0085

MAP-8963899

Plasma lipoprotein remodeling

2 of 29

2.3

1.01

0.0360

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0000562

Heart

2 of 217

1.43

0.94

0.0195

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005577

Fibrinogen complex

2 of 8

2.86

1.58

0.0062

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0797

Tissue remodeling

2 of 2

3.47

2.7

0.00018

KW-0280

Fibrinolysis

2 of 2

3.47

2.7

0.00018

KW-0420

Kringle

2 of 14

2.62

2.21

0.00071

KW-0720

Serine protease

2 of 43

2.13

1.55

0.0049

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR023317

Peptidase S1A, plasmin

2 of 2

3.47

1.8

0.0033

IPR003609

PAN/Apple domain

2 of 4

3.16

1.72

0.0041

IPR038178

Kringle superfamily

2 of 14

2.62

1.23

0.0190

IPR018056

Kringle, conserved site

2 of 13

2.65

1.23

0.0190

IPR000001

Kringle

2 of 14

2.62

1.23

0.0190

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00130

Kringle domain

2 of 14

2.62

1.49

0.0079

SM00462

Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain

2 of 26

2.35

1.33

0.0123

SM00020

Trypsin-like serine protease

2 of 63

1.97

0.91

0.0451

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