BN9_060030 protein (Albugo candida) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

BN9_060030

ZT_dimer domain-containing protein. (248 aa)

Predicted Functional Partners:

BN9_011150

0.581

BN9_073990

0.581

BN9_074000

0.581

Your Current Organism:

Albugo candida

NCBI taxonomy Id: 65357
Other names: A. candida, Aecidium candidum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BN9_011150	BN9_060030	A0A024G1A2	A0A024GF12	Uncharacterized protein; Belongs to the LDH/MDH superfamily.	ZT_dimer domain-containing protein.	0.581
BN9_011150	BN9_073990	A0A024G1A2	A0A024GI89	Uncharacterized protein; Belongs to the LDH/MDH superfamily.	Malate dehydrogenase.	0.935
BN9_011150	BN9_074000	A0A024G1A2	A0A024GIF5	Uncharacterized protein; Belongs to the LDH/MDH superfamily.	Malate dehydrogenase.	0.935
BN9_060030	BN9_011150	A0A024GF12	A0A024G1A2	ZT_dimer domain-containing protein.	Uncharacterized protein; Belongs to the LDH/MDH superfamily.	0.581
BN9_060030	BN9_073990	A0A024GF12	A0A024GI89	ZT_dimer domain-containing protein.	Malate dehydrogenase.	0.581
BN9_060030	BN9_074000	A0A024GF12	A0A024GIF5	ZT_dimer domain-containing protein.	Malate dehydrogenase.	0.581
BN9_073990	BN9_011150	A0A024GI89	A0A024G1A2	Malate dehydrogenase.	Uncharacterized protein; Belongs to the LDH/MDH superfamily.	0.935
BN9_073990	BN9_060030	A0A024GI89	A0A024GF12	Malate dehydrogenase.	ZT_dimer domain-containing protein.	0.581
BN9_074000	BN9_011150	A0A024GIF5	A0A024G1A2	Malate dehydrogenase.	Uncharacterized protein; Belongs to the LDH/MDH superfamily.	0.935
BN9_074000	BN9_060030	A0A024GIF5	A0A024GF12	Malate dehydrogenase.	ZT_dimer domain-containing protein.	0.581

Network Stats

number of nodes:

11

number of edges:

24

average node degree:

4.36

avg. local clustering coefficient:

0.913

expected number of edges:

11

PPI enrichment p-value:

0.000548

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015995

Chlorophyll biosynthetic process

5 of 19

1.9

2.4

5.97e-06

GO:0036068

Light-independent chlorophyll biosynthetic process

2 of 7

1.94

0.89

0.0205

GO:0019685

Photosynthesis, dark reaction

2 of 7

1.94

0.89

0.0205

GO:0019438

Aromatic compound biosynthetic process

6 of 226

0.91

0.67

0.0043

GO:0018130

Heterocycle biosynthetic process

6 of 243

0.88

0.63

0.0058

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016627

Oxidoreductase activity, acting on the CH-CH group of donors

3 of 22

1.62

0.73

0.0357

GO:0016730

Oxidoreductase activity, acting on iron-sulfur proteins as donors

2 of 5

2.09

0.73

0.0450

GO:0016636

Oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor

2 of 4

2.18

0.73

0.0450

GO:0051539

4 iron, 4 sulfur cluster binding

3 of 38

1.38

0.64

0.0450

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:30083465

(2018) Patterns in evolutionary origins of heme, chlorophyll a and isopentenyl diphosphate biosynthetic pathways suggest non-photosynthetic periods prior to plastid replacements in dinoflagellates.

4 of 22

1.74

1.11

0.0055

PMID:34295515

(2021) Characterizing the supercomplex association of photosynthetic complexes in cyanobacteria.

3 of 12

1.88

0.76

0.0356

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4585

Chlorophyll metabolic process

5 of 16

1.98

2.79

9.24e-07

CL:4583

Porphyrin-containing compound biosynthetic process

6 of 29

1.8

2.74

2.59e-07

CL:4587

Chlorophyll metabolic process

4 of 10

2.09

2.48

8.80e-06

CL:4589

Oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor, and Enoyl-(Acyl carrier protein) reductase

2 of 5

2.09

0.93

0.0183

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

can00860

Porphyrin and chlorophyll metabolism

5 of 55

1.44

1.56

6.64e-05

can01110

Biosynthesis of secondary metabolites

7 of 272

0.9

0.79

0.00032

can01100

Metabolic pathways

7 of 590

0.56

0.36

0.0311

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0149

Chlorophyll biosynthesis

3 of 13

1.85

1.25

0.0031

KW-0004

4Fe-4S

3 of 37

1.39

0.73

0.0259

KW-0602

Photosynthesis

3 of 58

1.2

0.59

0.0454

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00148

Nitrogenase component 1 type Oxidoreductase

2 of 2

2.48

0.85

0.0287

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