BN9_103830 protein (Albugo candida) - STRING interaction network

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second shell of interactors

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a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Coexpression

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Score

BN9_103830

Uncharacterized protein; Belongs to the histidinol dehydrogenase family. (427 aa)

Predicted Functional Partners:

BN9_097890

0.996

BN9_012640

0.986

BN9_088350

0.980

BN9_043520

0.976

BN9_094330

0.952

BN9_031960

0.945

BN9_084510

0.887

BN9_118330

0.815

BN9_130770

0.814

BN9_125920

0.814

Your Current Organism:

Albugo candida

NCBI taxonomy Id: 65357
Other names: A. candida, Aecidium candidum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BN9_012640	BN9_031960	A0A024G1F7	A0A024G6R1	Imidazoleglycerol-phosphate dehydratase; Belongs to the imidazoleglycerol-phosphate dehydratase family.	Uncharacterized protein; Belongs to the HisA/HisF family.	0.977
BN9_012640	BN9_043520	A0A024G1F7	A0A024G9Y4	Imidazoleglycerol-phosphate dehydratase; Belongs to the imidazoleglycerol-phosphate dehydratase family.	Uncharacterized protein.	0.961
BN9_012640	BN9_084510	A0A024G1F7	A0A024GL66	Imidazoleglycerol-phosphate dehydratase; Belongs to the imidazoleglycerol-phosphate dehydratase family.	Aminotran_1_2 domain-containing protein.	0.962
BN9_012640	BN9_088350	A0A024G1F7	A0A024GN92	Imidazoleglycerol-phosphate dehydratase; Belongs to the imidazoleglycerol-phosphate dehydratase family.	Aminotran_1_2 domain-containing protein.	0.997
BN9_012640	BN9_094330	A0A024G1F7	A0A024GNJ2	Imidazoleglycerol-phosphate dehydratase; Belongs to the imidazoleglycerol-phosphate dehydratase family.	Glutamine amidotransferase type-1 domain-containing protein; Belongs to the HisA/HisF family.	0.983
BN9_012640	BN9_097890	A0A024G1F7	A0A024GPX6	Imidazoleglycerol-phosphate dehydratase; Belongs to the imidazoleglycerol-phosphate dehydratase family.	PRA-CH domain-containing protein.	0.987
BN9_012640	BN9_103830	A0A024G1F7	A0A024GRD2	Imidazoleglycerol-phosphate dehydratase; Belongs to the imidazoleglycerol-phosphate dehydratase family.	Uncharacterized protein; Belongs to the histidinol dehydrogenase family.	0.986
BN9_012640	BN9_118330	A0A024G1F7	A0A024GTF5	Imidazoleglycerol-phosphate dehydratase; Belongs to the imidazoleglycerol-phosphate dehydratase family.	Uncharacterized protein; Belongs to the TrpA family.	0.481
BN9_012640	BN9_125920	A0A024G1F7	A0A024GV40	Imidazoleglycerol-phosphate dehydratase; Belongs to the imidazoleglycerol-phosphate dehydratase family.	Uncharacterized protein.	0.481
BN9_012640	BN9_130770	A0A024G1F7	A0A024FWJ1	Imidazoleglycerol-phosphate dehydratase; Belongs to the imidazoleglycerol-phosphate dehydratase family.	Uncharacterized protein.	0.481
BN9_031960	BN9_012640	A0A024G6R1	A0A024G1F7	Uncharacterized protein; Belongs to the HisA/HisF family.	Imidazoleglycerol-phosphate dehydratase; Belongs to the imidazoleglycerol-phosphate dehydratase family.	0.977
BN9_031960	BN9_043520	A0A024G6R1	A0A024G9Y4	Uncharacterized protein; Belongs to the HisA/HisF family.	Uncharacterized protein.	0.977
BN9_031960	BN9_084510	A0A024G6R1	A0A024GL66	Uncharacterized protein; Belongs to the HisA/HisF family.	Aminotran_1_2 domain-containing protein.	0.894
BN9_031960	BN9_088350	A0A024G6R1	A0A024GN92	Uncharacterized protein; Belongs to the HisA/HisF family.	Aminotran_1_2 domain-containing protein.	0.894
BN9_031960	BN9_094330	A0A024G6R1	A0A024GNJ2	Uncharacterized protein; Belongs to the HisA/HisF family.	Glutamine amidotransferase type-1 domain-containing protein; Belongs to the HisA/HisF family.	0.991
BN9_031960	BN9_097890	A0A024G6R1	A0A024GPX6	Uncharacterized protein; Belongs to the HisA/HisF family.	PRA-CH domain-containing protein.	0.989
BN9_031960	BN9_103830	A0A024G6R1	A0A024GRD2	Uncharacterized protein; Belongs to the HisA/HisF family.	Uncharacterized protein; Belongs to the histidinol dehydrogenase family.	0.945
BN9_031960	BN9_118330	A0A024G6R1	A0A024GTF5	Uncharacterized protein; Belongs to the HisA/HisF family.	Uncharacterized protein; Belongs to the TrpA family.	0.795
BN9_031960	BN9_125920	A0A024G6R1	A0A024GV40	Uncharacterized protein; Belongs to the HisA/HisF family.	Uncharacterized protein.	0.795
BN9_031960	BN9_130770	A0A024G6R1	A0A024FWJ1	Uncharacterized protein; Belongs to the HisA/HisF family.	Uncharacterized protein.	0.795

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

31

average node degree:

5.64

avg. local clustering coefficient:

0.903

expected number of edges:

11

PPI enrichment p-value:

3.04e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009073

Aromatic amino acid family biosynthetic process

6 of 17

2.31

4.48

6.10e-10

GO:0009423

Chorismate biosynthetic process

3 of 6

2.46

2.3

4.79e-05

GO:0008652

Cellular amino acid biosynthetic process

5 of 101

1.45

1.58

6.07e-05

GO:0009095

Aromatic amino acid family biosynthetic process, prephenate pathway

2 of 3

2.58

1.51

0.0017

GO:0019752

Carboxylic acid metabolic process

7 of 268

1.18

1.27

3.03e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016832

Aldehyde-lyase activity

3 of 6

2.46

1.95

0.00023

GO:0016829

Lyase activity

5 of 124

1.36

1.26

0.00047

GO:0003824

Catalytic activity

11 of 2380

0.42

0.33

0.0051

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005829

Cytosol

4 of 254

0.96

0.53

0.0373

GO:0005737

Cytoplasm

8 of 1168

0.59

0.39

0.0213

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:22238540

(2011) Natural product biosyntheses in cyanobacteria: A treasure trove of unique enzymes.

2 of 4

2.46

0.86

0.0272

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1191

Phenylalanine, tyrosine and tryptophan biosynthesis

6 of 21

2.21

4.26

1.00e-09

CL:953

Biosynthesis of amino acids, and Carbon metabolism

11 of 179

1.55

3.37

1.78e-14

CL:960

Pentose phosphate pathway, and Glycolytic process

5 of 23

2.1

3.21

1.64e-07

CL:1192

Aromatic amino acid biosynthesis, and Glycosyl transferase, family 3

4 of 16

2.16

2.66

4.44e-06

CL:1211

Chorismate biosynthetic process

3 of 6

2.46

2.34

3.91e-05

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

mar00400

Phenylalanine, tyrosine and tryptophan biosynthesis

6 of 19

2.26

4.88

4.18e-11

mar00710

Carbon fixation in photosynthetic organisms

5 of 19

2.18

3.92

5.06e-09

mar00030

Pentose phosphate pathway

5 of 19

2.18

3.92

5.06e-09

mar01230

Biosynthesis of amino acids

9 of 104

1.7

3.75

7.93e-13

mar01110

Biosynthesis of secondary metabolites

10 of 301

1.28

2.08

4.18e-11

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005737

Cytoplasm

8 of 1001

0.66

0.45

0.0120

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0057

Aromatic amino acid biosynthesis

4 of 14

2.21

2.76

3.31e-06

KW-0456

Lyase

4 of 87

1.42

1.23

0.00090

KW-0786

Thiamine pyrophosphate

2 of 10

2.06

1.06

0.0099

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF09364

XFP N-terminal domain

2 of 3

2.58

0.97

0.0172

PF02780

Transketolase, C-terminal domain

2 of 5

2.36

0.95

0.0180

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR029061

Thiamin diphosphate-binding fold

4 of 14

2.21

2.37

2.30e-05

IPR009014

Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II

3 of 8

2.33

1.76

0.00049

IPR005474

Transketolase, N-terminal

2 of 4

2.46

0.92

0.0210

IPR033248

Transketolase, C-terminal domain

2 of 5

2.36

0.9

0.0220

IPR005475

Transketolase-like, pyrimidine-binding domain

2 of 6

2.28

0.88

0.0235

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00861

Transketolase, pyrimidine binding domain

2 of 4

2.46

1.24

0.0053

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