BN9_105860 protein (Albugo candida) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

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Textmining

[Homology]

Score

BN9_105860

Uncharacterized protein. (738 aa)

Predicted Functional Partners:

BN9_054060

0.989

BN9_110480

0.989

BN9_070540

0.986

BN9_049550

0.942

BN9_089060

0.902

BN9_088310

0.894

BN9_088300

0.894

BN9_003590

0.818

BN9_065080

0.814

BN9_064420

0.802

Your Current Organism:

Albugo candida

NCBI taxonomy Id: 65357
Other names: A. candida, Aecidium candidum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BN9_003590	BN9_049550	A0A024FYJ0	A0A024GBC9	Uncharacterized protein.	Uncharacterized protein.	0.910
BN9_003590	BN9_054060	A0A024FYJ0	A0A024GD31	Uncharacterized protein.	Uncharacterized protein.	0.800
BN9_003590	BN9_065080	A0A024FYJ0	A0A024GGZ0	Uncharacterized protein.	Uncharacterized protein.	0.996
BN9_003590	BN9_070540	A0A024FYJ0	A0A024GHE1	Uncharacterized protein.	Uncharacterized protein.	0.817
BN9_003590	BN9_105860	A0A024FYJ0	A0A024GSE8	Uncharacterized protein.	Uncharacterized protein.	0.818
BN9_003590	BN9_110480	A0A024FYJ0	A0A024GSH2	Uncharacterized protein.	Vps53_N domain-containing protein.	0.799
BN9_049550	BN9_003590	A0A024GBC9	A0A024FYJ0	Uncharacterized protein.	Uncharacterized protein.	0.910
BN9_049550	BN9_054060	A0A024GBC9	A0A024GD31	Uncharacterized protein.	Uncharacterized protein.	0.857
BN9_049550	BN9_065080	A0A024GBC9	A0A024GGZ0	Uncharacterized protein.	Uncharacterized protein.	0.778
BN9_049550	BN9_070540	A0A024GBC9	A0A024GHE1	Uncharacterized protein.	Uncharacterized protein.	0.752
BN9_049550	BN9_089060	A0A024GBC9	A0A024FT59	Uncharacterized protein.	EGF-like domain-containing protein.	0.462
BN9_049550	BN9_105860	A0A024GBC9	A0A024GSE8	Uncharacterized protein.	Uncharacterized protein.	0.942
BN9_049550	BN9_110480	A0A024GBC9	A0A024GSH2	Uncharacterized protein.	Vps53_N domain-containing protein.	0.923
BN9_054060	BN9_003590	A0A024GD31	A0A024FYJ0	Uncharacterized protein.	Uncharacterized protein.	0.800
BN9_054060	BN9_049550	A0A024GD31	A0A024GBC9	Uncharacterized protein.	Uncharacterized protein.	0.857
BN9_054060	BN9_064420	A0A024GD31	A0A024GGS7	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.884
BN9_054060	BN9_065080	A0A024GD31	A0A024GGZ0	Uncharacterized protein.	Uncharacterized protein.	0.787
BN9_054060	BN9_070540	A0A024GD31	A0A024GHE1	Uncharacterized protein.	Uncharacterized protein.	0.986
BN9_054060	BN9_088300	A0A024GD31	A0A024GN87	Uncharacterized protein.	Uncharacterized protein.	0.836
BN9_054060	BN9_088310	A0A024GD31	A0A024GM09	Uncharacterized protein.	Uncharacterized protein.	0.836

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

27

average node degree:

4.91

avg. local clustering coefficient:

0.764

expected number of edges:

31

PPI enrichment p-value:

0.768

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016579

Protein deubiquitination

6 of 58

2.25

4.1

3.09e-09

GO:1903051

Negative regulation of proteolysis involved in protein catabolic process

3 of 12

2.63

2.18

9.31e-05

GO:0006511

Ubiquitin-dependent protein catabolic process

5 of 299

1.46

1.38

0.00036

GO:0030162

Regulation of proteolysis

4 of 240

1.45

1.08

0.0032

GO:0007094

Mitotic spindle assembly checkpoint signaling

2 of 15

2.36

1.05

0.0114

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004843

Cysteine-type deubiquitinase activity

5 of 48

2.25

3.42

1.26e-07

GO:0004197

Cysteine-type endopeptidase activity

5 of 71

2.08

3.16

2.01e-07

GO:0140096

Catalytic activity, acting on a protein

6 of 1524

0.83

0.51

0.0219

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005634

Nucleus

9 of 3640

0.63

0.42

0.0151

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9211

Mixed, incl. Peptidase C19, ubiquitin carboxyl-terminal hydrolase, and HELP motif

6 of 12

2.93

6.63

3.60e-13

CL:9129

Processing of Intronless Pre-mRNAs, and Peptidase C19, ubiquitin carboxyl-terminal hydrolase

7 of 53

2.35

5.7

9.91e-13

CL:9214

Regulation of protein localization to cell surface, and Peptidase C19, ubiquitin carboxyl-terminal hydrolase

4 of 6

3.06

4.33

1.14e-08

CL:5274

Mixed, incl. Male germ-line stem cell asymmetric division, and Meiotic sister chromatid cohesion

2 of 6

2.75

1.24

0.0056

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-5689880

Ub-specific processing proteases

4 of 182

1.57

1.11

0.0039

MAP-5688426

Deubiquitination

4 of 250

1.44

0.96

0.0068

MAP-141430

Inactivation of APC/C via direct inhibition of the APC/C complex

2 of 18

2.28

0.86

0.0266

MAP-141405

Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components

2 of 18

2.28

0.86

0.0266

MAP-179409

APC-Cdc20 mediated degradation of Nek2A

2 of 22

2.19

0.85

0.0266

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13423

Ubiquitin carboxyl-terminal hydrolase

3 of 13

2.6

2.16

0.00010

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001394

Peptidase C19, ubiquitin carboxyl-terminal hydrolase

4 of 22

2.49

2.88

3.41e-06

IPR028889

Ubiquitin specific protease domain

4 of 24

2.45

2.87

3.41e-06

IPR038765

Papain-like cysteine peptidase superfamily

5 of 101

1.93

2.52

3.41e-06

IPR018200

Ubiquitin specific protease, conserved site

3 of 20

2.41

1.93

0.00024

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