STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dnaJChaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] (375 aa)    
Predicted Functional Partners:
ACK70306.1
Beta-ketoacyl synthase; PFAM: alpha/beta hydrolase fold; sulfotransferase; AMP-dependent synthetase and ligase; short-chain dehydrogenase/reductase SDR; phosphopantetheine-binding; KR domain protein; Beta-ketoacyl synthase; Acyl transferase; KEGG: syp:SYNPCC7002_A1173 polyketide synthase.
  
 
 0.965
dnaK-3
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
 0.955
dnaK
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 0.949
dnaK-2
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
 
 0.934
ACK70840.1
PFAM: Heat shock protein 70; KEGG: fal:FRAAL2972 hypothetical protein; putative ricin B lectin and actin-like ATPase domains.
 
 0.922
ACK70841.1
Heat shock protein 70; PFAM: Tetratricopeptide TPR_2 repeat protein; Heat shock protein 70; SMART: Tetratricopeptide domain protein; KEGG: aau:AAur_3285 putative DnaK family protein.
 
 0.921
grpE
GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]
 
 
 0.905
ACK72536.1
PFAM: Respiratory-chain NADH dehydrogenase domain 51 kDa subunit; KEGG: mar:MAE_01090 bidirectional hydrogenase diaphorase subunit.
    
   0.881
ACK68641.1
PFAM: Heat shock protein 70; KEGG: mar:MAE_16770 heat shock protein 70.
  
 0.879
ACK71257.1
ATP-binding region ATPase domain protein; Molecular chaperone. Has ATPase activity.
  
 0.808
Your Current Organism:
Gloeothece citriformis
NCBI taxonomy Id: 65393
Other names: Cyanothece sp. PCC 7424, G. citriformis PCC 7424, Gloeothece citriformis PCC 7424, Synechococcus sp. ATCC 29155 (no longer available), Synechococcus sp. PCC 7424
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.